Clazosentan is a Small Molecule owned by Idorsia Pharmaceutical, and is involved in 10 clinical trials, of which 9 were completed, and 1 is ongoing.
Clazosentan (Pivlaz, ACT108475) is a selective endothelin-A (ET-A) receptor, antagonist. Endothelin-1 (ET-1) is a potent vasoconstrictor peptide produced by the vascular endothelium. The drug candidate reduces the frequency and severity of cerebral vasospasm following severe aneurysmal SAH.
The revenue for Clazosentan is expected to reach a total of $2.9bn through 2038. This change impacts the valuation of this asset and is an important factor to understand the current value of the drug in a clinical process. View the complete picture with the Clazosentan NPV Report.
Clazosentan Sodium (Pivlaz) is an anti cerebral vasospastic agent. It is formulated as solution for intravenous route of administration. Pivlaz is indicated for the prevention of cerebral vasospasm, vasospasm-related cerebral infarction and cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage (aSAH).
Idorsia Pharmaceutical Overview
Idorsia Pharmaceutical (Idorsia) is a biopharmaceutical company that discovers, develops, and commercializes small molecules to treat the central nervous system and cardiovascular and immunological disorders. It is investigating daridorexant against insomnia; aprocitentan for the treatment of resistant hypertension; clazosentan to treat cerebral vasospasm associated with aneurysmal subarachnoid hemorrhage; and L-lucerastat compound targeting fabry disease. The company is also evaluating drugs against suspected acute myocardial infarction, systemic lupus erythematosus, Binge eating disorder, and rare lysosomal storage disorders. It works in collaboration with Janssen Biotech to develop and commercialize Aprocitentan drug candidates. Idorsia is headquartered in Allschwil, Switzerland.
The company reported revenues of (Swiss Francs) CHF35.4 million for the fiscal year ended December 2021 (FY2021), a decrease of 50.7% over FY2020. The operating loss of the company was CHF613 million in FY2021, compared to an operating loss of CHF410.6 million in FY2020. The net loss of the company was CHF634.6 million in FY2021, compared to a net loss of CHF444.8 million in FY2020. The company reported revenues of CHF21 million for the third quarter ended September 2022, an increase of 23.1% over the previous quarter.
Quick View – Clazosentan
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