CM-24 is under clinical development by Purple Biotech and currently in the Phase I and Phase II in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.

According to GlobalData, the latest event to affect CM-24’s likelihood of approval (LoA) and phase transition for Melanoma took place on 14 Dec 2022, which increased the likelihood that the drug progresses to the next phase in its clinical pathway and increased the likelihood of final approval for this indication.

GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their CM-24 Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.

CM-24 overview

CM-24 is under development for pancreatic cancer, melanoma, non-small cell lung cancer, metastatic pancreatic cancer, metastatic adenocarcinoma of the pancreas , papillary thyroid cancer, and colorectal cancer. The therapeutic candidate is administered by intravenous route. CM-24 is a humanized immunoglobulin G4 (IgG4) (kappa) isotype immune-modulating monoclonal antibody that binds to CEACAM1, a protein used by cancer cells to suppress the immune system. It was under development for the treatment of metastatic melanoma, bladder, gastric, colorectal and ovarian cancer.

Purple Biotech overview

Purple Biotech, formerly known as Kitov Pharma Ltd, is a pharmaceutical company that develops novel therapies to control tumor immune evasion and drug resistance in cancer treatments. The company’s lead product candidate consensi is a non-steroidal anti-inflammatory drug is used for the treatment of osteoarthritis pain and hypertension. Its product pipeline includes CM-24 a monoclonal antibody being developed to treat non-small cell lung cancer and NT-219 a small molecule targeting head and neck cancer. The company works in partnership with Bristol Myers Squibb, Coeptis Pharmaceuticals, CSBio and Kuhnil Pharmaceuticals to develop and commercialize its pipeline products. Purple Biotech is headquartered in Tel Aviv, Israel.

Quick View CM-24 LOA Data

Report Segments
  • Innovator
Drug Name
  • CM-24
Administration Pathway
  • Intravenous
Therapeutic Areas
  • Oncology
Key Developers
Highest Development Stage
  • Phase II

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.