Danvilostomig is under clinical development by Systimmune and currently in Phase II for Nasopharyngeal Cancer. According to GlobalData, Phase II drugs for Nasopharyngeal Cancer does not have sufficient historical data to build an indication benchmark PTSR for Phase II. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the Danvilostomig LoA Report. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Danvilostomig overview
Danvilostomig (SIB-003) is under development for the treatment of solid tumors including metastatic solid tumors including colorectal cancer, human epidermal growth factor receptor 2 negative breast cancer, melanoma, recurrent head and neck squamous cell carcinoma, non-small cell lung cancer, urothelial cancer, triple-negative breast cancer, cervical cancer, head and neck squamous cell carcinoma, oral cavity cancer, small-cell lung cancer, endometrial cancer, fallopian tube cancer, peritoneal cancer, epithelial ovarian cancer, vulvar cancer, vaginal cancer, nasopharyngeal cancer and primary sarcoma of the gynecological reproductive system, oropharyngeal cancer, hypopharyngeal cancer, laryngeal cancer, gastric cancer, gastroesophageal junction (GEJ) adenocarcinoma, esophageal cancer, gastrointestinal tumor and advanced renal cell carcinoma. The drug candidate is a bi-specific antibody acts by targeting two check point inhibitors of EGFR family. It is developed based on bi-specific engineering SEBA platform. It is administered through intravenous route. It was also under development for the treatment of lung cancer, kidney cancer and glioblastoma multiforme. It acts by targeting programmed cell death protein 1 (PD1) and cytotoxic T lymphocyte protein 4 (CTLA4).
Systimmune overview
Systimmune is a biopharmaceutical company that develops novel therapies for the treatment of cancer. The company’s technology platforms for the discovery and development of novel bio-therapeutics include antibody discovery platform to manufacture target-specific IgG producing B cells using novel miniaturized immuno-assays; process development platform to manufacture bio-therapeutics and multi-specific antibody engineering platforms. Its pipeline portfolio includes bi-specific antibodies, antibody conjugates, and immuno-oncology products for the treatment of non-small cell lung cancer, glioblastoma, colon, neck, head, breast, nasopharyngeal, kidney and liver cancers. These antibodies act through systematic intervention to trigger the immune response on the cancer cells. Systimmune is headquartered in Redmond, Washington, the US.
For a complete picture of Danvilostomig’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
