DFL-24412 is under clinical development by Dompe Farmaceutici and currently in Phase II for Chronic Low Back Pain (CLBP). According to GlobalData, Phase II drugs for Chronic Low Back Pain (CLBP) have a 57% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how DFL-24412’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

DFL-24412 overview

DFL-24412 is under development for the treatment of chronic low back pain. The drug candidate is a ternary drug-drug co-crystal of ketoprofen, lysine and gabapentin (KLS-GABA co-crystal). It is administered through oral route. It acts by targeting voltage-dependent calcium channel subunit alpha2/delta1 (CACNA2D1), subunit alpha2/delta2 (CACNA2D2), cylooxygenase-1 (COX-1) and cylooxygenase-2 (COX-2).

Dompe Farmaceutici overview

Dompe Farmaceutici (Dompe) is a biopharmaceutical company that includes research and development of innovative solutions. The company product pipeline includes ophtha – NGF, NETosis – reparixin, NETosis – ladarixin and primary care – KLS-gaba. Its products treat neurotrophic keratitis, sjogren-related dry eye, back-of-the-eye, community-acquired pneumonia (CAP), acute respiratory distress syndrome (ARDS), type 1 diabetes – early onset and insulin resistant. Dompe offers its product in therapeutic areas such as pain and anti-inflammatory, cough and cold, eye, skin, oral care and cardiovascular gastro. The company has operations in the US and China. Dompe is headquartered in Milan, Italy.

For a complete picture of DFL-24412’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.