Dsuvia is a Small Molecule owned by AcelRx Pharmaceuticals, and is involved in 25 clinical trials, of which 20 were completed, 2 are ongoing, and 3 are planned.
Sufentanil is a Mu opioid receptor agonist. It interacts predominately with the opioid mu-receptor. These mu-binding sites are discretely distributed in the human brain, spinal cord, and other tissues. Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited.
The revenue for Dsuvia is expected to reach a total of $1.7bn through 2038. This change impacts the valuation of this asset and is an important factor to understand the current value of the drug in a clinical process. View the complete picture with the Dsuvia NPV Report.
Dsuvia is currently owned by AcelRx Pharmaceuticals.
Sufentanil citrate (Dzuveo, ARX-F01, Dsuvia) is an anilide derivative, acts as an opioid anesthetic agent with analgesic properties. It is formulated as tablets for the sublingual route of administration. Dzuveo is indicated for the management of acute moderate to severe pain and in adults in a certified medically supervised healthcare setting, such as hospitals, surgical centers, and emergency departments, for the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate
Sufentanil citrate (ARX-04) is under development for the treatment of moderate-to-severe acute pain in a medically supervised setting, including medically supervised patients in an emergency, outpatient or ambulatory surgery, non-surgical patients experiencing pain and post-operative pain in patients, after short-stay surgery. The drug candidate is developed based on NanoTab technology.
AcelRx Pharmaceuticals Overview
AcelRx Pharmaceuticals (AcelRx), is a specialty pharmaceutical company that develops and commercializes drugs for the treatment of pain. The company’s lead product candidate, Dsuvia (known as Dzuveo in Europe), is a single sufentanil sublingual tablet for treating of moderate-to-severe acute pain. Its pipeline also includes Zalviso (for US market), a drug and device combination product for the management of moderate to severe acute pain in adults. AcelRx developed a proprietary, non-invasive, sublingual formulation technology to deliver its highly lipophilic drugs. The company commercializes its EC-approved Zalviso under a license agreement with Grunenthal in Europe and Australia. AcelRx is headquartered in Hayward, California, the US.
The company reported revenues of (US Dollars) US$2.8 million for the fiscal year ended December 2021 (FY2021), a decrease of 48% over FY2020. The operating loss of the company was US$36 million in FY2021, compared to an operating loss of US$41 million in FY2020. The net loss of the company was US$35.1 million in FY2021, compared to a net loss of US$40.4 million in FY2020. The company reported revenues of US$0.5 million for the third quarter ended September 2022, a decrease of 49.9% over the previous quarter.
Quick View – Dsuvia
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