Elanco Animal Health patented an eye-drop composition for diagnosing and treating herpetic eye infections in companion animals. The composition includes 2-amino-9-[[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl]-1,9-dihydro-6H-Purin-6-one and a cyclodextrin. GlobalData’s report on Elanco Animal Health gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Elanco Animal Health, NSAID cancer drugs was a key innovation area identified from patents. Elanco Animal Health's grant share as of February 2024 was 46%. Grant share is based on the ratio of number of grants to total number of patents.
A recently granted patent (Publication Number: US11904024B2) discloses a composition comprising 2-amino-9-[[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl]-1,9-dihydro-6H-Purin-6-one and a cyclodextrin, with the former present at a concentration of at least 0.1% w/v and the latter at least 10% w/v. The composition is specified to be an aqueous solution, particularly designed as an ophthalmic solution. Additionally, the inclusion of hydroxypropyl beta-cyclodextrin and thiomersal at a concentration of at least 0.008% w/v is highlighted in the claims.
Moreover, the patent claims cover the use of this composition as a diagnostic or therapeutic agent, specifically for treating ocular herpetic infections in companion animals, particularly felines. The method involves applying the composition onto the eye two or three times per day for a minimum of seven days. Furthermore, the patent details a method for preparing the ophthalmic solution, involving the solubilization of 2-amino-9-[[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl]-1,9-dihydro-6H-Purin-6-one in a cyclodextrin solution, with the optional addition of thiomersal. The cyclodextrin specified in the method is hydroxypropyl beta-cyclodextrin, ensuring the stability and efficacy of the final ophthalmic solution.
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