Eltanexor is under clinical development by Karyopharm Therapeutics and currently in Phase II for Metastatic Castration-Resistant Prostate Cancer (mCRPC). According to GlobalData, Phase II drugs for Metastatic Castration-Resistant Prostate Cancer (mCRPC) have a 33% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Eltanexor’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Eltanexor overview

Eltanexor is under development for the treatment of myelodysplastic syndrome, It was also under development for the treatment of acute myeloid leukemia (AML), metastatic hormone refractory (castration-resistant, androgen-independent) prostate cancer, acute myeloid leukemia (AML), adenocarcinoma of prostate and colon or rectum, relapsed or refractory multiple myeloma, metastatic colorectal cancer, refractory multiple myeloma. The drug candidate is administered orally. KPT-8602 acts by targeting exportin 1 and is a second generation SINE compound. The development is based on the selective inhibitor of nuclear export (SINE) technology platform.

It was also under development for the treatment of acute lymphoblastic leukemia, diffuse large B-cell lymphoma, myelofibrosis, chronic lymphocytic leukemia (CLL), gastric cancer, gastroesophageal (GE) junction carcinomas, triple-negative breast cancer (TNBC), squamous cell carcinoma of the penis, nasopharyngeal cancer.

Karyopharm Therapeutics overview

Karyopharm Therapeutics (Karyopharm) discovers and develops novel drugs for the treatment of cancer and other diseases. The company’s core technology harnesses the inhibition of nuclear export as a mechanism to treat patients suffering from cancer. Karyopharm’s lead product, Xpovio, is being developed for the treatment of multiple myeloma, and relapsed or refractory diffuse large B-cell lymphoma. Its pipeline drug candidates include selinexor, eltanexor, verdinexor, and KPT-9274. Karyopharm’s drug candidates are indicated for the treatment of various hematological and solid tumor malignancies including multiple myeloma, diffuse large B-cell lymphoma, liposarcoma, glioblastoma and endometrial cancer. The company has operations in the US, Israel and Germany. Karyopharm is headquartered in Newton, Massachusetts, the US.

For a complete picture of Eltanexor’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.