ETBX-011 is under clinical development by ImmunityBio and currently in the Phase II in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.

According to GlobalData, the latest event to affect ETBX-011’s likelihood of approval (LoA) and phase transition for Metastatic Colorectal Cancer took place on 13 Dec 2021, which decreased the likelihood that the drug progresses to the next phase in its clinical pathway and decreased the likelihood of final approval for this indication.

GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their ETBX-011 Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.

ETBX-011 overview

ETBX-011 is under development for the treatment of carcinoembryonic antigen (CEACAM5)-expressing cancer which is HER2+ breast cancer, metastatic colorectal cancer. The vaccine, Ad5 [E1-, E2B-]-CEA(6D) is given by subcutaneous injection. The vaccine candidate is developed by utilizing adenovirus vector vaccine (AVVP) technology.  It was also under development for the treatment of metastatic lung cancer, metastatic breast cancer and pancreatic cancer.

ImmunityBio overview

ImmunityBio, formerly NantKwest, a clinical-stage biotechnology company is developing therapies and vaccines that complement, harness and amplify the immune system to defeat cancers and infectious diseases. The company product pipeline includes n-803 + bcg for bladder cancer, anktiva + pd-l1 t-hank for lung cancer, anktiva + aldox +pd-l1 t-hank for pancreatic cancer, her2 t-hank for glioblastoma and anktiva + m-cenk for advanced solid tumor. ImmunityBio Anktiva, a lead candidate Anktiva are a novel class of biopharmaceuticals that enhance the therapeutic potential of cytokines, and promote lymphocyte infiltration at a site of disease, improving immune response. The company has operation in Korea, Italy and the US. ImmunityBio is headquartered in San Diego, California, the US.

Quick View ETBX-011 LOA Data

Report Segments
  • Innovator
Drug Name
  • ETBX-011
Administration Pathway
  • Subcutaneous
Therapeutic Areas
  • Oncology
Key Developers
Highest Development Stage
  • Phase II

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.