Fruquintinib is under clinical development by Hutchison MediPharma and currently in Phase II for Soft Tissue Sarcoma. According to GlobalData, Phase II drugs for Soft Tissue Sarcoma have a 27% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Fruquintinib’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Fruquintinib overview

Fruquintinib (Elunate) is an anti-neoplastic agent. It is formulated as hard gelatin capsules for oral route of administration. Elunate is indicated for the treatment of metastatic colorectal cancer patients, who have failed at least two prior systemic antineoplastic therapies including fluoropyrimidine, oxaliplatin and irinotecan, with or without prior use of anti-vascular endothelial growth factor or anti-epidermal growth factor receptor therapies.

Fruquintinib (HMPL-013) is under development for the treatment of locally advanced rectal cancer, desmoplastic small round cell tumor, epithelioid hemangioendothelioma, solitary fibroma, angiosarcoma, soft tissue sarcoma, advanced or metastatic triple negative breast cancer, HER2 negative breast cancer, metastatic colorectal adenocarcinoma, metastatic renal cell carcinoma, metastatic biliary tract adenocarcinoma, advanced solid tumor including gastric cancer, gastroesophageal junction adenocarcinoma and advanced non squamous non small cell lung cancer, ovarian cancer, endometrial cancer, cervical cancer, breast cancer, advanced or recurrent/metastatic pancreatic adenocarcinoma and meningioma. It is administered orally. It was also under development for hepatocellular carcinoma and thymic cancer.

Hutchison MediPharma overview

Hutchison MediPharma (HMPL) carries out discovery, development and commercialization of therapeutics in oncology and autoimmune diseases. The company’s products include savolitinib, fruquintinib, sulfatinib, HMPL-523, epitinib, theliatinib, HMPL-453, HMPL-689 and HMPL-004. It develops drug discovery technologies in molecular and cell biology, high throughput screening, genomics and informatics to support research and development projects. HMPL’s research and development programs comprise gene-targeted and cell-based screening assays, ligand-dependent screening assays and signal transduction pathway screening assays. The company’s products serve in the fields of medicinal chemistry, pharmacology, oncology, cardiovascular and respiratory diseases, and antiviral treatments. It operates through its two offices in Pudong, China. HMPL is headquartered in Pudong, China.

For a complete picture of Fruquintinib’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.