Geron. has filed a patent for the synthesis of orthogonally protected 3′-amino nucleoside monomers. The method involves selectively protecting the 3′-amino group while leaving the nucleoside base unprotected. Claim 1 details the process for preparing adenosine, guanosine, or cytidine monomers with protected nucleoside bases and 3′-amino groups. GlobalData’s report on Geron gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Geron, Peptide pharmacophores was a key innovation area identified from patents. Geron's grant share as of January 2024 was 48%. Grant share is based on the ratio of number of grants to total number of patents.
Method for synthesizing orthogonally protected 3'-amino nucleoside monomers
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A recently filed patent (Publication Number: US20240034748A1) describes a method for preparing adenosine, guanosine, or cytidine monomers with protected nucleoside bases and 3'-amino groups. The method involves providing a monomer with an unprotected 3'-amino-3'-deoxy base, selectively reacting the 3'-amino group with a protecting group, reacting the 5'-hydroxyl group with another protecting group, and reacting the nucleoside base with a third protecting group. Importantly, the protecting groups can be selectively removed without affecting the other protected groups, allowing for precise control over the deprotection process.
The patent also includes a series of canceled claims, indicating a focus on the specific method outlined in claim 1 for preparing nucleoside monomers with protected bases and 3'-amino groups. This method could have significant implications for the synthesis of nucleoside analogs and other compounds where precise protection and deprotection steps are crucial. By providing a detailed and controlled approach to protecting nucleoside bases and 3'-amino groups, this patent may offer a valuable tool for researchers and industry professionals working in the field of nucleoside chemistry.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
