Geron has filed a patent for a method of preparing an amorphous solid composition of a fatty acid metal salt. The method involves contacting a succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane organic salt with a metal base to produce a metal salt, which is then precipitated in a solvent to create the amorphous solid composition. The patent also includes a specific example of an amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane lithium salt. GlobalData’s report on Geron gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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Preparation of amorphous solid composition of fatty acid metal salt
A recently filed patent (Publication Number: US20230192597A1) describes an amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane lithium salt. The patent claims specify various characteristics and properties of this salt.
According to claim 24, the fatty acid used in the amorphous salt can be selected from a group that includes palmitic acid, stearic acid, oleic acid, linoleic acid, myristoleic acid, and batyl fatty acid. However, claim 25 specifically mentions that palmitic acid is the fatty acid used in the salt.
Claim 26 states that the protected hydroxy group in the salt contains a dimethoxy-triphenylmethyl protecting group. This protecting group helps to preserve the hydroxy functionality of the compound.
The patent also provides information about the structure of the succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane lithium salt. Claim 27 states that it is a compound of Formula I, although the specific structure of Formula I is not provided in the claims.
The amorphous salt described in the patent has certain characteristic features. Claim 28 mentions that it exhibits an X-ray powder diffraction pattern (XRPD) with a peak at approximately 19.5° in 2?. This XRPD pattern can be used to identify and characterize the salt.
Thermogravimetric analysis (TGA) is used to study the thermal stability of the amorphous salt. Claim 29 states that the TGA of the salt shows a single weight loss step, which begins at around 225°C. Additionally, claim 31 specifies that the mass loss of the sample upon heating from 30°C to 300°C is less than 1% of the total mass.
Differential scanning calorimetry (DSC) is another technique used to analyze the properties of the amorphous salt. Claim 32 mentions that the salt exhibits an absorption peak at approximately 44.9°C in the DSC thermogram.
Overall, this patent describes an amorphous solid succinylated 3-(fatty acid amido)-2-hydroxy-1-(protected hydroxy)-propane lithium salt with specific characteristics and properties. The claims provide information about the composition, structure, and various analytical features of the salt.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
