Grifols has patented a device for electron-beam sterilization of flexible bags containing human plasma protein solutions. The device includes two electron accelerators emitting beams at specific energies, creating a sterilization zone. This innovation allows for in-line filling processes for flexible bags, ensuring safe therapeutic use. GlobalData’s report on Grifols gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Grifols, Attenuated virus-based vaccines was a key innovation area identified from patents. Grifols's grant share as of January 2024 was 51%. Grant share is based on the ratio of number of grants to total number of patents.

Sterilization device for flexible bags containing plasma protein solutions

Source: United States Patent and Trademark Office (USPTO). Credit: Grifols SA

The granted patent (Publication Number: US11850315B2) discloses a combination of a device and a flexible bag designed for sterilization purposes. The device includes a first accelerator emitting an electron beam with energies between 400-500 keV and a second accelerator emitting an electron beam with an energy of at least 4 MeV. The sterilization zone is defined as the space between the first and second accelerators and the flexible bag, ensuring the bag is within the electron beams. The arrangement involves the accelerators being horizontally adjacent to each other and vertically adjacent to the flexible bag, with a distance between them ranging from 1.5 cm to 7 cm.

Furthermore, the patent details the specific configurations of the accelerators, with the second accelerator emitting electron beams within the range of 4-5 MeV. The device is positioned in a radiation-proof area with containment measures such as walls and floors at least 65-cm thick, made of lead, to prevent the escape of radiation emitted by the electron accelerators. This setup ensures the safe and effective sterilization of the flexible bag while minimizing radiation exposure to surrounding areas, highlighting the importance of safety measures in such processes.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies