Gunagratinib is under clinical development by InnoCare Pharma and currently in Phase II for Metastatic Bile Duct Cancer. According to GlobalData, Phase II drugs for Metastatic Bile Duct Cancer have a 71% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Gunagratinib’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Gunagratinib overview

Gunagratinib (ICP-192) is under development for the treatment of cholangiocarcinoma with FGFR2 fusions and urothelial cancer with FGFR2/3 genetic alterations, solid tumors with head and neck cancer with FGFR2 aberrations, metastatic bile duct cancer (metastatic intrahepatic cholangiocarcinoma). It is administered an oral route as a tablet. It acts by targeting FGFR1, FGFR2, FGFR3 and FGFR4 (pan-FGFR).

InnoCare Pharma overview

InnoCare Pharma (InnoCare) is a biopharmaceutical company that discovers and develops novel treatments for cancer and autoimmune diseases. The company’s pipeline product portfolio includes ICP-022 a Bruton Tyrosine Kinase (BTK) inhibitor to treat B cell malignancies; ICP-105, an inhibitor for the treatment of hepatocellular carcinoma (HCC); ICP-192 a novel compound that targets gene abnormalities in solid tumor. It serves in the therapeutic areas of gastrointestinal cancer, liver cancer, lupus and rheumatoid arthritis. The company builds a fully integrated biopharmaceutical platform with strong in-house research and development capabilities, including drug target identification and verification, preclinical evaluation, clinical trial design and execution, drug manufacturing and quality control. It has operational presence in the US and China. InnoCare is headquartered in Changping, Beijing, China.

For a complete picture of Gunagratinib’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.