The pharmaceuticalindustry continues to be a hotbed of patent innovation. Activity is driven by the evolution of treatment paradigms, and the gravity of unmet needs, as well as the growing importance of technologies such as pharmacogenomics, digital therapeutics, and artificial intelligence. In the last three years alone, there have been over 787,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Cell & gene therapy in pharma: recombinant adeno-associated virus (rAAV) production technologyBuy the report here.

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According to GlobalData’s Technology Foresights, which uses over 668,000 patents to analyze innovation intensity for the pharmaceutical industry, there are 80+ innovation areas that will shape the future of the industry.

rAAV production technology is a key innovation area in cell & gene therapy

rAAV production technology refers to the development and optimization of methods for efficient production and modification of recombinant adeno-associated viruses (rAAVs) for gene therapy applications. This includes, but is not limited to, optimizing vector design, selecting appropriate host cells and vectors, and developing efficient purification methods for scalable production.

GlobalData’s analysis also uncovers the companies at the forefront of each innovation area and assesses the potential reach and impact of their patenting activity across different applications and geographies. According to GlobalData, there are 190+ companies, spanning technology vendors, established pharmaceutical companies, and up-and-coming start-ups engaged in the development and application of rAAV production technology.

Key players in rAAV production technology – a disruptive innovation in the pharmaceutical industry

‘Application diversity’ measures the number of applications identified for each patent. It broadly splits companies into either ‘niche’ or ‘diversified’ innovators.   

‘Geographic reach’ refers to the number of countries each patent is registered in. It reflects the breadth of geographic application intended, ranging from ‘global’ to ‘local’.  

Patent volumes related to rAAV production technology

Company Total patents (2010 - 2022) Premium intelligence on the world's largest companies
Sanofi 560 Unlock Company Profile
C. H. Boehringer Sohn 456 Unlock Company Profile
Voyager Therapeutics 214 Unlock Company Profile
Adverum Biotechnologies 190 Unlock Company Profile
UniQure 188 Unlock Company Profile
Children's Hospital of Philadelphia 154 Unlock Company Profile
BioMarin Pharmaceutical 147 Unlock Company Profile
Zoetis 138 Unlock Company Profile
Massachusetts Eye and Ear Infirmary 137 Unlock Company Profile
RegenxBio 129 Unlock Company Profile
Takeda Pharmaceutical 117 Unlock Company Profile
F. Hoffmann-La Roche 110 Unlock Company Profile
4D Molecular Therapeutics 102 Unlock Company Profile
Regeneron Pharmaceuticals 102 Unlock Company Profile
Genethon 94 Unlock Company Profile
Sangamo Therapeutics 84 Unlock Company Profile
Pfizer 77 Unlock Company Profile
Eli Lilly 75 Unlock Company Profile
Merck 72 Unlock Company Profile
Ultragenyx Pharmaceutical 71 Unlock Company Profile
Johnson & Johnson 69 Unlock Company Profile
MediGene 63 Unlock Company Profile
StrideBio 60 Unlock Company Profile
Takara 60 Unlock Company Profile
Nationwide Children's Hospital 52 Unlock Company Profile
Virovek 48 Unlock Company Profile
Centre National de la Recherche Scientifique 47 Unlock Company Profile
Homology Medicines 44 Unlock Company Profile
Virginia Tech Intellectual Property 43 Unlock Company Profile
Tenaya Therapeutics 40 Unlock Company Profile
Virbac Group 38 Unlock Company Profile
Danaher 35 Unlock Company Profile
Children's Medical Center 35 Unlock Company Profile
Massachusetts General Hospital 34 Unlock Company Profile
Benitec Biopharma 33 Unlock Company Profile
Lonza Group 32 Unlock Company Profile
Mayo Clinic 32 Unlock Company Profile
City of Hope 31 Unlock Company Profile
Verneuil Participations 28 Unlock Company Profile
Oxford BioMedica 27 Unlock Company Profile
Codiak BioSciences 27 Unlock Company Profile
Applied Genetic Technologies 27 Unlock Company Profile
German Cancer Research Center 26 Unlock Company Profile
Fondazione Telethon 25 Unlock Company Profile
MeiraGTx 24 Unlock Company Profile
GE HealthCare Technologies 21 Unlock Company Profile
GSK 21 Unlock Company Profile
NEW HOPE, CITY OF 21 Unlock Company Profile
St. Jude Children’s Research Hospital 20 Unlock Company Profile
WuXi AppTec 19 Unlock Company Profile

Source: GlobalData Patent Analytics

Sanofi is one of the leading patent filers in rAAV production technology. Sanofi is a major pharmaceutical company engaged in the discovery, development, manufacturing, and marketing of a wide range of medicines and vaccines. Its portfolio includes medicines for the treatment of cancer, rare diseases, and multiple sclerosis, human vaccines for protection against various bacterial and viral diseases, and other indications. The company also offers consumer healthcare products for digestion, allergy, respiratory conditions, pain, women’s health, as well as vitamins, minerals, and supplements. Sanofi's R&D efforts focus on advancing a combination drug to increase the effectiveness of treatments and on advancing the formulation of new biologics to produce precision medicines. C. H. Boehringer Sohn and Voyager Therapeutics are some of the other key patent filers in rAAV production technology.

In terms of application diversity, Zoetis leads the pack, while German Cancer Research Center and Merck & Co stood in the second and third positions, respectively. By means of geographic reach, 4D Molecular Therapeutics held the top position, followed by Zoetis and Sanofi.

To further understand the key themes and technologies disrupting the pharmaceutical industry, access GlobalData’s latest thematic research report on Pharmaceutical.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Patent Analytics tracks patent filings and grants from official offices around the world. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.