The pharmaceutical industry continues to be a hotbed of patent innovation. Activity is driven by the evolution of treatment paradigms, and the gravity of unmet needs, as well as the growing importance of technologies such as pharmacogenomics, digital therapeutics, and artificial intelligence. In the last three years alone, there have been over 787,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Genomics in pharma: telomerase reverse transcriptase (TERT) screeningBuy the report here.

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According to GlobalData’s Technology Foresights, which uses over 668,000 patents to analyze innovation intensity for the pharmaceutical industry, there are 80+ innovation areas that will shape the future of the industry.

TERT screening is a key innovation area in genomics

TERT gene promoter mutations lead to constitutive activation and expression. This, in turn, leads to replication and proliferation of cancer cells. Mutations in the TERT promoter are found in melanomas, glioblastoma multiforme, hepatocellular carcinoma, bladder cancer, basal cell carcinoma, cutaneous squamous cell carcinoma, and thyroid cancers. Bi-directional Sanger sequencing is performed using PCR primers designed to target mutations in the promoter region of TERT.

GlobalData’s analysis also uncovers the companies at the forefront of each innovation area and assesses the potential reach and impact of their patenting activity across different applications and geographies. According to GlobalData, there are 50+ companies, spanning technology vendors, established pharmaceutical companies, and up-and-coming start-ups engaged in the development and application of TERT screening.

Key players in TERT screening – a disruptive innovation in the pharmaceutical industry

‘Application diversity’ measures the number of applications identified for each patent. It broadly splits companies into either ‘niche’ or ‘diversified’ innovators.   

‘Geographic reach’ refers to the number of countries each patent is registered in. It reflects the breadth of geographic application intended, ranging from ‘global’ to ‘local’.  

Patent volumes related to TERT screening

Company Total patents (2010 - 2022) Premium intelligence on the world's largest companies
F. Hoffmann-La Roche 113 Unlock Company Profile
Immatics 88 Unlock Company Profile
Bio-Techne 85 Unlock Company Profile
Oxford Biodynamics 70 Unlock Company Profile
Elixirgen 61 Unlock Company Profile
Commonwealth Scientific and Industrial Research Organisation 41 Unlock Company Profile
Johnson & Johnson 35 Unlock Company Profile
Takeda Pharmaceutical 34 Unlock Company Profile
German Cancer Research Center 34 Unlock Company Profile
Myriad Genetics 31 Unlock Company Profile
Novartis 29 Unlock Company Profile
Pfizer 29 Unlock Company Profile
Grains Research and Development 28 Unlock Company Profile
Bayer 25 Unlock Company Profile
Ferring 25 Unlock Company Profile
Abbott Laboratories 20 Unlock Company Profile
Geron 20 Unlock Company Profile
Suzhou Neupharma 19 Unlock Company Profile
AstraZeneca 17 Unlock Company Profile
Advaxis 16 Unlock Company Profile
Agios Pharmaceuticals 16 Unlock Company Profile
Children's Medical Center 15 Unlock Company Profile
ProvIncial Health Services Authority 14 Unlock Company Profile
Viracta Therapeutics 14 Unlock Company Profile
Guangzhou Baiyunshan Pharmaceutical 14 Unlock Company Profile
IRCCS Policlinico San Donato 14 Unlock Company Profile
Havah Therapeutics 12 Unlock Company Profile
Bayer Pharma (Bayer Schering Pharma) 12 Unlock Company Profile
EpicentRx 12 Unlock Company Profile
Fondazione Telethon 12 Unlock Company Profile
The Corporation For Penn State 12 Unlock Company Profile
Cancer Research UK 10 Unlock Company Profile
NanoString Technologies 10 Unlock Company Profile
GSK 10 Unlock Company Profile
Dong Wha Pharma 9 Unlock Company Profile
Inbiomotion SL 9 Unlock Company Profile
Madrigal Pharmaceuticals 9 Unlock Company Profile
Mayo Clinic 7 Unlock Company Profile
VitaPath Genetics 7 Unlock Company Profile
Genelux 7 Unlock Company Profile
Merck 6 Unlock Company Profile
The Cleveland Clinic Foundation 6 Unlock Company Profile
AbbVie 4 Unlock Company Profile
Galapagos 4 Unlock Company Profile
Centre National Research Scientific 3 Unlock Company Profile
Fundacio Privada Institucio Catalana De Recera I Estudis Avancats 3 Unlock Company Profile
Ninovax 3 Unlock Company Profile
Hospital Clinic of Barcelona 3 Unlock Company Profile
Foundation for the Promotion of Health and Biomedical Research of Valencia 3 Unlock Company Profile
Vivoryon Therapeutics 3 Unlock Company Profile

Source: GlobalData Patent Analytics

F. Hoffmann-La Roche (Roche) is one of the leading patent filers in TERT screening. Roche is a biotechnology company that develops drugs and diagnostics to treat major diseases. The company offers in vitro diagnostics, tissue-based cancer diagnostics, and diabetes management solutions. Roche conducts research to identify novel methods to prevent, diagnose, and treat diseases. The company has developed several screening methods to identify the mutations in several targets. Immatics and Elixirgen are some of the other key patent filers in TERT screening

In terms of application diversity, GSK leads the pack, while Merck and Johnson & Johnson stood in the second and third positions, respectively. By means of geographic reach, Elixirgen held the top position, followed by Johnson & Johnson and Takeda Pharmaceutical.

To further understand the key themes and technologies disrupting the pharmaceutical industry, access GlobalData’s latest thematic research report on Genomics.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Patent Analytics tracks patent filings and grants from official offices around the world. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.