The pharmaceutical industry continues to be a hotbed of innovation, with activity driven by the evolution of new treatment paradigms, and the gravity of unmet needs, as well as the growing importance of technologies such as pharmacogenomics, digital therapeutics, and artificial intelligence. In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Immuno-oncology in Pharmaceuticals: Gene therapy delivery using viral vectors. Buy the report here.

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According to GlobalData’s Technology Foresights, which uses over 756,000 patents to analyse innovation intensity for the pharmaceutical industry, there are 110 innovation areas that will shape the future of the industry.

Gene therapy delivery using viral vectors is a key innovation area in immuno-oncology

Viruses such as retrovirus, lentiviruses, alphaviruses, adenovirus, adeno-associated virus (AAV), and herpes simplex virus, have been modified in the laboratory for use in gene therapy applications. Viruses are evolved in highly efficient way at delivering nucleic acid to specific cell types while avoiding immunosurveillance by an infected host. Viral vectors have been used as a part of gene therapies for the treatment of diseases such as cardiovascular, muscular, ophthalmologic, hematologic, metabolic, infectious diseases and cancer.

GlobalData’s analysis also uncovers the companies at the forefront of each innovation area and assesses the potential reach and impact of their patenting activity across different applications and geographies.  According to GlobalData, there are 140+ companies, spanning technology vendors, established pharmaceutical companies, and up-and-coming start-ups engaged in the development and application of gene therapy delivery using viral vectors.

Key players in gene therapy delivery using viral vectors – a disruptive innovation in the pharmaceutical industry

‘Application diversity’ measures the number of different applications identified for each relevant patent and broadly splits companies into either ‘niche’ or ‘diversified’ innovators.

‘Geographic reach’ refers to the number of different countries each relevant patent is registered in and reflects the breadth of geographic application intended, ranging from ‘global’ to ‘local’.

Patent volumes related to gene therapy delivery using viral vectors

Company Total patents (2010 - 2022) Premium intelligence on the world's largest companies
Sanofi 507 Unlock Company Profile
Takeda Pharmaceutical 200 Unlock Company Profile
Sangamo Therapeutics 158 Unlock Company Profile
Adverum Biotechnologies 155 Unlock Company Profile
RegenxBio 150 Unlock Company Profile
Vascular Biogenics 121 Unlock Company Profile
Genethon 106 Unlock Company Profile
Nationwide Children's Hospital 94 Unlock Company Profile
Precigen 91 Unlock Company Profile
BioMarin Pharmaceutical 85 Unlock Company Profile
Children's Hospital of Philadelphia 80 Unlock Company Profile
Centre National de la Recherche Scientifique 76 Unlock Company Profile
Fondazione Telethon 73 Unlock Company Profile
Eli Lilly and 69 Unlock Company Profile
Voyager Therapeutics 69 Unlock Company Profile
4D Molecular Therapeutics 69 Unlock Company Profile
Pfizer 58 Unlock Company Profile
Encoded Therapeutics 57 Unlock Company Profile
City of Hope 57 Unlock Company Profile
Akouos 50 Unlock Company Profile
Esteve Pharmaceuticals 47 Unlock Company Profile
F. Hoffmann-La Roche 45 Unlock Company Profile
Biogen 44 Unlock Company Profile
Applied Genetic Technologies 44 Unlock Company Profile
UniQure 41 Unlock Company Profile
Selecta Biosciences 40 Unlock Company Profile
Amicus Therapeutics 39 Unlock Company Profile
Avalo Therapeutics 39 Unlock Company Profile
Bayer 37 Unlock Company Profile
MeiraGTx Holdings 34 Unlock Company Profile
Children's Medical Center 34 Unlock Company Profile
Regeneron Pharmaceuticals 33 Unlock Company Profile
Astellas Pharma 31 Unlock Company Profile
St. Jude Children’s Research Hospital 31 Unlock Company Profile
Decibel Therapeutics 30 Unlock Company Profile
Mayo Clinic 30 Unlock Company Profile
IRCCS Policlinico San Donato 29 Unlock Company Profile
Intellia Therapeutics 28 Unlock Company Profile
Institut de Myologie 26 Unlock Company Profile
Eyeserv 26 Unlock Company Profile
bluebird bio 26 Unlock Company Profile
CSL 26 Unlock Company Profile
Homology Medicines 25 Unlock Company Profile
Tenaya Therapeutics 24 Unlock Company Profile
Corporation For Penn State 23 Unlock Company Profile
Utilities Service Alliance 23 Unlock Company Profile
American Gene Technologies International 23 Unlock Company Profile
Massachusetts General Hospital 23 Unlock Company Profile
Ovid Therapeutics 21 Unlock Company Profile
Japan Science and Technology Agency 21 Unlock Company Profile

Source: GlobalData Patent Analytics

Sanofi is one of the leading patent filers working with viral vectors. Genomic medicine researchers at Sanofi are accelerating progress toward gene and cell therapies using an array of technologies, from nucleic acid nanostructures to viral and non-viral gene-delivery platforms. The research and development (R&D) teams collaborate across disease areas to address challenges in genetic rare and neurological diseases, as well as some common diseases.

In terms of application diversity, Avalo Therapeutics is the top company, followed by Amicus Therapeutics and Pfizer. By means of geographic reach, Intellia Therapeutics holds the top position, while Esteve Pharmaceuticals and BioMarin Pharmaceutical are in the second and third positions, respectively.

To further understand the key themes and technologies disrupting the pharmaceutical industry, access GlobalData’s latest thematic research report on Immuno-Oncology – Thematic Research.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Patent Analytics tracks patent filings and grants from official offices around the world. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.