The pharmaceutical industry continues to be a hotbed of patent innovation. Activity is driven by the evolution of treatment paradigms, and the gravity of unmet needs, as well as the growing importance of technologies such as pharmacogenomics, digital therapeutics, and artificial intelligence. In the last three years alone, there have been over 787,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Precision and personalized medicine in pharma: personalized cancer vaccinesBuy the report here.

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According to GlobalData’s Technology Foresights, which uses over 668,000 patents to analyze innovation intensity for the pharmaceutical industry, there are 80+ innovation areas that will shape the future of the industry.

Personalized cancer vaccines is a key innovation area in precision and personalized medicine

Personalized cancer vaccines refer to vaccines that are tailored to a particular patient’s tumor and are designed to recognize and attack cancer cells. These vaccines are created by identifying the specific somatic mutations in a patient’s tumor and use this information to create a cancer mutation signature that can be used to develop a vaccine that targets the patient’s cancer cells.

GlobalData’s analysis also uncovers the companies at the forefront of each innovation area and assesses the potential reach and impact of their patenting activity across different applications and geographies. According to GlobalData, there are 250+ companies, spanning technology vendors, established pharmaceutical companies, and up-and-coming start-ups engaged in the development and application of personalized cancer vaccines.

Key players in personalized cancer vaccines – a disruptive innovation in the pharmaceutical industry

‘Application diversity’ measures the number of applications identified for each patent. It broadly splits companies into either ‘niche’ or ‘diversified’ innovators.   

‘Geographic reach’ refers to the number of countries each patent is registered in. It reflects the breadth of geographic application intended, ranging from ‘global’ to ‘local’.  

Patent volumes related to personalized cancer vaccines

Company Total patents (2021 - 2023) Premium intelligence on the world's largest companies
Immatics 1879 Unlock Company Profile
F. Hoffmann-La Roche 737 Unlock Company Profile
BioNTech 219 Unlock Company Profile
Bristol-Myers Squibb 189 Unlock Company Profile
Regeneron Pharmaceuticals 165 Unlock Company Profile
Novartis 139 Unlock Company Profile
AstraZeneca 136 Unlock Company Profile
Memorial Sloan Kettering Cancer Center 123 Unlock Company Profile
Merck 99 Unlock Company Profile
Massachusetts General Hospital 93 Unlock Company Profile
Fate Therapeutics 83 Unlock Company Profile
NantWorks 76 Unlock Company Profile
Gritstone Bio 75 Unlock Company Profile
Mereo BioPharma 5 74 Unlock Company Profile
TRON 72 Unlock Company Profile
Sanofi 70 Unlock Company Profile
Advaxis 69 Unlock Company Profile
Johnson & Johnson 58 Unlock Company Profile
C. H. Boehringer Sohn 57 Unlock Company Profile
Replimune Group 55 Unlock Company Profile
CARsgen Therapeutics 53 Unlock Company Profile
Snipr Technologies 53 Unlock Company Profile
Mayo Clinic 50 Unlock Company Profile
Amgen 49 Unlock Company Profile
Compagnie Merieux Alliance 47 Unlock Company Profile
Merrimack Pharmaceuticals 47 Unlock Company Profile
Editas Medicine 46 Unlock Company Profile
Precision Biosciences 44 Unlock Company Profile
Samsung Group 42 Unlock Company Profile
Nant 41 Unlock Company Profile
CRISPR Therapeutics 39 Unlock Company Profile
EXUMA Biotech 38 Unlock Company Profile
Pfizer 37 Unlock Company Profile
Moderna 36 Unlock Company Profile
Cedars-Sinai Health System 36 Unlock Company Profile
CareGroup 36 Unlock Company Profile
Zoetis 34 Unlock Company Profile
Ipsen 32 Unlock Company Profile
GSK 31 Unlock Company Profile
Prothena 30 Unlock Company Profile
Genocea Biosciences 30 Unlock Company Profile
Seagen 29 Unlock Company Profile
Intellia Therapeutics 29 Unlock Company Profile
Tocagen 28 Unlock Company Profile
Gilead Sciences 28 Unlock Company Profile
PT Soho Global Health 26 Unlock Company Profile
bluebird bio 25 Unlock Company Profile
Children's Medical Center 23 Unlock Company Profile
Leap Therapeutics 22 Unlock Company Profile
Jounce Therapeutics 22 Unlock Company Profile

Source: GlobalData Patent Analytics

Immatics is one of the leading patent filers in personalized cancer vaccines. The biopharmaceutical company is focused on the development of T cell immunotherapies to fight against cancer. Immatics’ XPRESIDENT technology platform helps in the identification of targets for T-cell based immunotherapies and their optimization. All XPRESIDENT peptides are sourced from native tumors including primary tissues and metastatic biopsies as well as tissues derived, and as a result the therapy is considered as personalized therapy. F. Hoffmann-La Roche and BioNTech are some of the other key patent filers in personalized cancer vaccines.

In terms of application diversity, EXUMA Biotech leads the pack, while Fate Therapeutics and CRISPR Therapeutics stood in the second and third positions, respectively. By means of geographic reach, Replimune Group held the top position, followed by Immatics and Genocea Biosciences.

To further understand the key themes and technologies disrupting the pharmaceutical industry, access GlobalData’s latest thematic research report on Precision and Personalized Medicine in Pharma.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Patent Analytics tracks patent filings and grants from official offices around the world. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.