The pharmaceutical industry continues to be a hotbed of innovation, with activity driven by the evolution of new treatment paradigms, and the gravity of unmet needs, as well as the growing importance of technologies such as pharmacogenomics, digital therapeutics, and artificial intelligence. In the last three years alone, there have been over 633,000 patents filed and granted in the pharmaceutical industry, according to GlobalData’s report on Small molecules in Pharmaceuticals: Quinoline derivatives as anticancer agents. Buy the report here.

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According to GlobalData’s Technology Foresights, which uses over 756,000 patents to analyse innovation intensity for the pharmaceutical industry, there are 110 innovation areas that will shape the future of the industry.

Quinoline derivatives is a key innovation area for anticancer agents

Quinolines are heterocyclic aromatic organic compounds with the chemical formula C9H7N. The structure of quinoline is represented by the fusion of benzene ring with pyridine at two neighbouring carbon atoms. Quinoline can be either derived from natural sources or synthesised artificially. Cuspareine, Cusparine, Galipine, Vasicine, Echinopsine, Nitidine, Lavendamycin, Chelerythrine, Dictamnine, Camptothecin, and Chelidonine are some of the naturally existing quinoline alkaloids with potent anticancer activity.

GlobalData’s analysis also uncovers the companies at the forefront of each innovation area and assesses the potential reach and impact of their patenting activity across different applications and geographies.  According to GlobalData, there are 60+ companies, spanning technology vendors, established pharmaceutical companies, and up-and-coming start-ups engaged in the development and application of quinoline derivatives as anticancer agents.

Key players in quinoline derivatives as anticancer agents – a key innovation area in the pharmaceutical industry

‘Application diversity’ measures the number of different applications identified for each relevant patent and broadly splits companies into either ‘niche’ or ‘diversified’ innovators.

‘Geographic reach’ refers to the number of different countries each relevant patent is registered in and reflects the breadth of geographic application intended, ranging from ‘global’ to ‘local’.

Patent volumes related to quinoline derivatives as anticancer agents

Company Total patents (2010 - 2022) Premium intelligence on the world's largest companies
Exelixis 380 Unlock Company Profile
Vertex Pharmaceuticals 357 Unlock Company Profile
Bristol-Myers Squibb 278 Unlock Company Profile
Sanofi 228 Unlock Company Profile
AbbVie 108 Unlock Company Profile
F. Hoffmann-La Roche 86 Unlock Company Profile
Aerie Pharmaceuticals 84 Unlock Company Profile
Pfizer 74 Unlock Company Profile
Bayer 64 Unlock Company Profile
Biogen 56 Unlock Company Profile
E. Merck 55 Unlock Company Profile
FibroGen 53 Unlock Company Profile
Otsuka Holdings 50 Unlock Company Profile
GSK 47 Unlock Company Profile
NMS Group 46 Unlock Company Profile
Advenchen Laboratories 44 Unlock Company Profile
Les Laboratoires Servier 42 Unlock Company Profile
Fujifilm Holdings 39 Unlock Company Profile
Precigen 38 Unlock Company Profile
Shenzhen Chipscreen Biosciences 37 Unlock Company Profile
Johnson & Johnson 34 Unlock Company Profile
Beijing Konruns Pharmaceutical 30 Unlock Company Profile
VM Discovery 29 Unlock Company Profile
LEO Foundation 28 Unlock Company Profile
Max Planck Society 26 Unlock Company Profile
Cytokinetics 25 Unlock Company Profile
Second Genome 24 Unlock Company Profile
Zhejiang DTRM Biopharma 21 Unlock Company Profile
Amgen 21 Unlock Company Profile
Oncternal Therapeutics 21 Unlock Company Profile
Kirin Holdings 20 Unlock Company Profile
Eisai 20 Unlock Company Profile
National Cancer Center 19 Unlock Company Profile
Genoscience Pharma 19 Unlock Company Profile
Oncore Biopharma 18 Unlock Company Profile
Microbial Chemistry Research Foundation 18 Unlock Company Profile
TaiRx 17 Unlock Company Profile
Vivace Therapeutics 15 Unlock Company Profile
NoNO 15 Unlock Company Profile
Takeda Pharmaceutical 14 Unlock Company Profile
Evotec 14 Unlock Company Profile
Infinity Pharmaceuticals 13 Unlock Company Profile
Cancer Research UK 13 Unlock Company Profile
ExonHit Therapeutics 13 Unlock Company Profile
Max-Planck-Gesellschaft 12 Unlock Company Profile
Merck & Co 12 Unlock Company Profile
Evotec (Us) 12 Unlock Company Profile
Yuhan 11 Unlock Company Profile
DCB-USA 11 Unlock Company Profile
BioMarin Pharmaceutical 11 Unlock Company Profile

Source: GlobalData Patent Analytics

Exelixis is one of the leading patent filers of quinoline derivatives as anticancer agents. Exelixis is a biopharmaceutical company that focuses on the development and commercialisation of small molecules for the treatment of cancer. The company’s products Cometriq and Cabometyx are quinoline derivatives developed for the treatment of patients with advanced renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC).

In terms of application diversity, Precigen is the top company, followed by Biogen and LEO Foundation. By means of geographic reach, Cytokinetics holds the top position. Zhejiang DTRM Biopharma and Oncore Biopharma stand in second and third positions, respectively. 

To further understand the key themes and technologies disrupting the pharmaceutical industry, access GlobalData’s latest thematic research report on Pharmaceutical.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Patent Analytics tracks patent filings and grants from official offices around the world. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies across the world’s largest industries.