Iovance Biotherapeutics has been granted a patent for improved methods to expand and produce therapeutic populations of TILs, including gene-editing for enhanced efficacy. The gene-edited TIL composition includes silenced immune checkpoint genes PD-1 and TIGIT, leading to increased IFN-? secretion. GlobalData’s report on Iovance Biotherapeutics gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Iovance Biotherapeutics, Cytokine activate T-cell based compositions was a key innovation area identified from patents. Iovance Biotherapeutics's grant share as of January 2024 was 18%. Grant share is based on the ratio of number of grants to total number of patents.

Gene-edited til composition with enhanced therapeutic efficacy

Source: United States Patent and Trademark Office (USPTO). Credit: Iovance Biotherapeutics Inc

A recently granted patent (Publication Number: US11866688B2) discloses a gene-edited tumor infiltrating lymphocyte (TIL) composition designed for therapeutic purposes. The composition includes a therapeutic population of gene-edited TILs with silenced or reduced expression of immune checkpoint genes PD-1 and TIGIT, leading to increased IFN-? secretion by at least five-fold compared to non-expanded TILs. This enhanced secretion is crucial for immune response modulation in cancer treatment.

Furthermore, the gene-edited TIL composition is capable of exhibiting IFN-? secretion greater than 1000 pg/ml, making it a potent tool in the fight against various cancers such as melanoma, ovarian cancer, lung cancer, and more. The composition is cryopreserved, ensuring its stability and viability for future therapeutic applications. The patent highlights the potential of gene-edited TILs in enhancing immune responses against cancer, offering a promising avenue for personalized and effective cancer treatment strategies.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies