Ipatasertib is under clinical development by Genentech USA and currently in the Phase I, Phase II and Phase III in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.

According to GlobalData, the latest event to affect Ipatasertib’s likelihood of approval (LoA) and phase transition for Metastatic Hormone Refractory (Castration Resistant, Androgen-Independent) Prostate Cancer took place on 04 Nov 2022, which increased the likelihood that the drug progresses to the next phase in its clinical pathway.

GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their Ipatasertib Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.

Ipatasertib overview

Ipatasertib (RG-7440/GDC-0068) is under development for the treatment of metastatic solid tumors including advanced or metastatic HER2-positive breast cancer, epithelial ovarian cancer, fallopian tube cancer, peritoneal cancer, castration-resistant prostate cancer in previously untreated patients and also patients treated with docetaxel chemotherapy, metastatic and hormone receptor-positive, HER2-negative breast cancer, glioblastoma mulitforme, melanoma, locally advanced or metastatic gastric or gastroesophageal junction adenocarcinoma. The drug candidate is administered orally in the form of tablets and capsules.  It is a small molecule with antineoplastic activity. Ipatasertib targets the serine/threonine protein kinase Akt (protein kinase B). It was also under development for neoadjuvant triple negative breast cancer, endometrial cancer and prostate cancer.

Genentech USA overview

Genentech USA (Genentech), a subsidiary of F. Hoffmann-La Roche Ltd, is a biotechnology company that discovers, develops, manufactures and commercializes medicines to address serious medical needs. It offers drugs in various therapeutic areas including oncology, immunology, ophthalmology, metabolism, neurology, and infectious disease, among others. Its pipeline products include Emicizumab (RG6013, ACE910), a bispecific monoclonal antibody used to replace the function of protein in the blood clotting process; and Entrectinib (RXDX-101, RG6268), a CNS-active tyrosine-kinase inhibitor intended for the treatment of non-small cell lung cancer; among others. The company has partnership with BioLineRx, Charles River Laboratories International, Amunix, among others. Genentech is headquartered in South San Francisco, California, the US.

Quick View Ipatasertib LOA Data

Report Segments
  • Innovator
Drug Name
  • Ipatasertib
Administration Pathway
  • Oral
Therapeutic Areas
  • Oncology
Key Developers
Highest Development Stage
  • Phase III

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.