Iscalimab is a Monoclonal Antibody owned by Novartis, and is involved in 15 clinical trials, of which 8 were completed, 6 are ongoing, and 1 is planned.

Iscalimab is a Fc-silent anti-CD40 antibody. The drug candidate inhibits the interaction of CD40 ligand binding to CD40 which results in T cell mediated immune responses suppression. The CD40 stimulation results in the T cell priming and T cell-mediated effector functions and also upregulate costimulatory molecules and activate macrophages, NK cells, and endothelia as well as participate in organ-specific autoimmune disease, graft rejection.

The revenue for Iscalimab is expected to reach a total of $456m through 2038. This change impacts the valuation of this asset and is an important factor to understand the current value of the drug in a clinical process. View the complete picture with the Iscalimab NPV Report.

Iscalimab was originated by Chiron and is currently owned by Novartis. XOMA is the other company associated in development or marketing of Iscalimab.

Iscalimab Overview

Iscalimab is under development for the treatment of type 1 diabetes mellitus,  myasthenia gravis, primary Sjogren's syndrome, lupus nephritis and moderate to severe hidradenitis suppurativa. The drug candidate is administered through intravenous and subcutaneous routes. The drug candidate is an anti-CD40 monoclonal antibody. It was under development for the treatment of Grave's hyperthyroidism and rheumatoid arthritis. It was under development for the treatment of kidney transplant rejection and liver transplant rejection.

Novartis Overview

Novartis is a healthcare company that focuses on the discovery, development, manufacture and marketing of prescription and generic pharmaceutical products and eye care products. It provides drugs for the treatment of cancer, cardiovascular diseases, dermatological conditions, neurological disorders, ophthalmic and respiratory diseases, immune disorders, and infections, among others. The company offers generic medicines and biosimilars through Sandoz. Novartis conducts research in various disease areas through The Novartis Institutes for BioMedical Research (NIBR). The company operates through a network of subsidiaries and offices across the Americas, Europe, the Middle East, Africa, and Asia-Pacific. Novartis is headquartered in Basel, Switzerland.

The company reported revenues of (US Dollars) US$52,877 million for the fiscal year ended December 2021 (FY2021), an increase of 6% over FY2020. In FY2021, the company’s operating margin was 22.1%, compared to an operating margin of 20.3% in FY2020. In FY2021, the company recorded a net margin of 45.4%, compared to a net margin of 16.2% in FY2020. The company reported revenues of US$12,842 million for the third quarter ended September 2022, a decrease of 1.9% over the previous quarter.

Quick View – Iscalimab

Report Segments
  • Innovator
Drug Name
  • Iscalimab
Administration Pathway
  • Intravenous
  • Subcutaneous
Therapeutic Areas
  • Dermatology
  • Hormonal Disorders
  • Immunology
  • Metabolic Disorders
Key Companies
  • Sponsor Company: Novartis
  • Originator: Chiron
Highest Development Stage
  • Phase II

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, potential applicable patients, drug margins, company expenses, and pricing estimates. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate rNPV, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA)and phase transition success rate(PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.