JNJ-8543 is under clinical development by Johnson & Johnson and currently in Phase I for Nodal Marginal Zone B-Cell Lymphoma. According to GlobalData, Phase I drugs for Nodal Marginal Zone B-Cell Lymphoma have a 100% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how JNJ-8543’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

JNJ-8543 overview

JNJ-80948543 is under development for the treatment of chronic lymphocytic leukemia (CLL), waldenstrom macroglobulinemia (lymphoplasmacytic lymphoma), mantle cell lymphoma, follicular lymphoma, diffuse large b-cell lymphoma, marginal zone b-cell lymphoma including nodal marginal zone b-cell lymphoma, extranodal marginal zone b-cell lymphoma (mucosa-associated lymphoid tissue or malt-lymphoma), splenic marginal zone b-cell lymphoma, hematological malignancies. The drug candidate is administered through subcutaneous route. It is a T-cell redirecting tri-specific antibody that recognizes the cluster of differentiation 3 (CD3) on T lymphocytes and surface antigens on mature healthy and malignant B-lymphocytes.

Johnson & Johnson overview

Johnson & Johnson (J&J) researches, develops, manufactures, and sells pharmaceutical products, medical devices, and consumer products. The company provides pharmaceuticals for immune diseases, cancer, neurological disorders, infectious, cardiovascular and metabolic diseases; consumer products in oral care, baby care, beauty, over-the-counter (OTC) medicines, women’s health and wound care categories; and medical devices for use in the cardiovascular, orthopaedic, general surgery and vision care fields. J&J distributes pharmaceutical and medical products to retailers, wholesalers, health care professionals and hospitals; and offers consumer products through retail outlets and distributors. The company offers its products in the US; Europe; Asia-Pacific and Africa; and Western Hemisphere (excluding the US). J&J is headquartered in New Brunswick, New Jersey, the US.

For a complete picture of JNJ-8543’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.