KA-2507 is under clinical development by Karus Therapeutics and currently in Phase I for Solid Tumor. According to GlobalData, Phase I drugs for Solid Tumor have a 54% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how KA-2507’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

KA-2507 overview

KA-2507 is under development for the treatment of melanoma, solid tumors including colorectal cancer, adenoid cystic carcinoma, metastatic biliary tract cancer including extra-hepatic, ampullary cancer and gallbladder cancer. It is formulated as a capsule and administered through the oral route. The drug candidate acts by targeting HDAC6. It was also under development for multiple myeloma. The drug candidate is a new chemical entity.

Karus Therapeutics overview

Karus Therapeutics (Karus) operates as a drug development company that designs and develops cancer therapies. The company offers small molecule drugs with immunotherapy for the treatment of hematological and solid tumors. Its pipeline products include KA2507 and KA2237 inhibitors. Karus’ KA2507 is a highly selective inhibitor of HDAC6 for the treatment of multiple myeloma and inflammatory diseases. The company’s KA2237 is a dual selective inhibitor of P13K for the treatment of solid tumors and hematological cancers. Its development programs offer medical needs in the fields of chronic inflammation, retaining drug design, immunotherapeutic modes, haematological malignancies and solid tumours. Karus is headquartered in Oxford, the UK.

For a complete picture of KA-2507’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.