Larotrectinib sulfate is a Small Molecule owned by Bayer, and is involved in 22 clinical trials, of which 9 were completed, 10 are ongoing, and 3 are planned.

Larotrectinib (LOXO-101) is a pan tropomyosin receptor kinase inhibitor. Trk is a signaling protein that gives the cell instructions. Trk consists of a family of three receptors, which sit on the cell surface, known as TrkA, TrkB, and TrkC, which are encoded by the NTRK1, NTRK2, and NTRK3 genes. Trk as a translocation partner in gene fusion leads to constitutive activation of a signaling pathway, leading to cancer. The drug candidate inhibits pan Trk, regulates the signaling pathway and suppresses the growth of tumors.

The revenue for Larotrectinib sulfate is expected to reach a total of $6.7bn through 2038. This change impacts the valuation of this asset and is an important factor to understand the current value of the drug in a clinical process. View the complete picture with the Larotrectinib sulfate NPV Report.

Larotrectinib sulfate was originated by Array BioPharma and is currently owned by Bayer.

Larotrectinib sulfate Overview

Larotrectinib Sulfate (Vitrakvi) is a anti-neoplastic agent. It is formulated as solution and hard gelatin capsules for oral route of administration. Vitrakvi is indicated for the treatment of adult and pediatric patients with solid tumors that have a neurotrophic receptor tyrosine kinase (NTRK) gene fusion without a known acquired resistance mutation are metastatic or where surgical resection is likely to result in severe morbidity, have no satisfactory alternative treatments or that have progressed following treatment, neurotrophic receptor tyrosine kinase (NTRK) fusion gene positive advanced or recurrent.

Larotrectinib (LOXO-101) is under development for the treatment of solid tumors such as pancreatic cancer, colon cancer, non-small cell lung cancer, soft tissue sarcoma, thyroid cancer, colorectal cancer, salivary gland cancer, biliary tumor, melanoma, bile duct cancer (Cholangiocarcinoma), secretory breast cancer, non-Hodgkin lymphomas, Langerhans cell histiocytosis (LCH), juvenile xanthogranuloma (JXG), histiocytic sarcoma, multiple myeloma, intrinsic brain stem tumors, optic pathway gliomas, pineal tumors, head and neck cancer squamous cell carcinoma, fibrosarcoma, gastrointestinal stromal tumor (GIST) including appendiceal cancer, pontine glioma, pancreatic cancer, ovarian cancer, kidney cancer, astrocytoma,neuroblastoma and cancers with a NTRK1, NTRK2, or NTRK3 gene fusion. It is administered orally. It targets pan tropomyosin receptor kinases (TrkA, TrkB, and TrkC). The drug candidate is developed based on Array drug discovery platform.

Bayer Overview

Bayer is engaged in the discovery, development, manufacturing, and commercialization of products for human health, and agriculture. It provides medicines for cardiovascular diseases, women’s health, cancer, hematology, ophthalmology and other indications. It also strives to develop new molecules and technologies for use in the fields of medicine and modern agriculture. The company’s product portfolio includes prescription products, specialty pharmaceuticals, diagnostic imaging equipment, non-prescription (over the counter or OTC) products, seeds, crop protection solutions and non-agricultural pest control solutions. Bayer markets its healthcare and crop protection products essentially through wholesalers, pharmacies, hospitals and retailers. It operates through a network of subsidiaries in Asia-Pacific, Europe, North America, Latin America, Africa and the Middle East. Bayer is headquartered in Leverkusen, North Rhine-Westphalia, Germany.

The company reported revenues of (Euro) EUR44,081 million for the fiscal year ended December 2021 (FY2021), an increase of 6.5% over FY2020. The operating profit of the company was EUR3,353 million in FY2021, compared to an operating loss of EUR16,169 million in FY2020. The net profit of the company was EUR1,000 million in FY2021, compared to a net loss of EUR10,495 million in FY2020. The company reported revenues of EUR11,281 million for the third quarter ended September 2022, a decrease of 12% over the previous quarter.

Quick View – Larotrectinib sulfate

Report Segments
  • Innovator (NME)
Drug Name
  • Larotrectinib sulfate
Administration Pathway
  • Oral
Therapeutic Areas
  • Genetic Disorders
  • Oncology
Key Companies
Highest Development Stage
  • Marketed

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, potential applicable patients, drug margins, company expenses, and pricing estimates. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate rNPV, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA)and phase transition success rate(PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.