Laruparetigene zovaparvovec is a Gene Therapy owned by Applied Genetic Technologies, and is involved in 2 clinical trials, which are ongoing.

Laruparetigene zovaparvovec (AGTC-501) acts by activating RPGR, a photoreceptor ciliary protein which is expressed predominantly in the retina. Mutation in RPGR gene leads to progressive loss of rod and cone vision. Gene therapy replaces broken gene with normal copy of functioning RPGR gene. The functional RPGR gene provides instructions for making a protein that is essential for normal vision.

The revenue for Laruparetigene zovaparvovec is expected to reach a total of $1.3bn through 2038. This change impacts the valuation of this asset and is an important factor to understand the current value of the drug in a clinical process. View the complete picture with the Laruparetigene zovaparvovec NPV Report.

Laruparetigene zovaparvovec is originated and owned by Applied Genetic Technologies.

Laruparetigene zovaparvovec Overview

Laruparetigene zovaparvovec (AGTC-501) is under development for the treatment of X-linked retinitis pigmentosa (XLRP). It is administered through subretinal injection and acts by targeting X-linked retinitis pigmentosa GTPase regulator (RPGR). The gene therapy is developed based on adeno-associated virus (AAV) vector technology platform.

Applied Genetic Technologies Overview

Applied Genetic Technologies (AGTC) is a pharmaceutical company. The company Invovled in development of eye disease cures. AGTC develops treatments for patients that have diseases caused by broken genes. It offers products such X-linked retinitis pigmentosa, achromatopsia, bionic sight, age-related macular degeneration,non-syndromic hearing loss and deafness,frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The company’s achromatopsia provides treatment for inherited conditions that are associated with visual acuity loss, extreme light sensitivity resulting in daytime blindness, and total loss of color discrimination. AGTC’s x-linked retinoschisis offers treatment in retinal degeneration affecting young males, presenting with poor vision by school age. The company also offers ophthalmology development programs and proof-of-concept data in multiple indications. AGTC is headquartered in Alachua, Florida, the US Applied Genetic Technologies (AGTC) is a pharmaceutical company. The company Invovled in development of eye disease cures. AGTC develops treatments for patients that have diseases caused by broken genes. It offers products such X-linked retinitis pigmentosa, achromatopsia, bionic sight, age-related macular degeneration,non-syndromic hearing loss and deafness,frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The company’s achromatopsia provides treatment for inherited conditions that are associated with visual acuity loss, extreme light sensitivity resulting in daytime blindness, and total loss of color discrimination. AGTC’s x-linked retinoschisis offers treatment in retinal degeneration affecting young males, presenting with poor vision by school age. The company also offers ophthalmology development programs and proof-of-concept data in multiple indications. AGTC is headquartered in Alachua, Florida, the US

Quick View – Laruparetigene zovaparvovec

Report Segments
  • Innovator
Drug Name
  • Laruparetigene zovaparvovec
Administration Pathway
  • Intraocular
Therapeutic Areas
  • Ophthalmology
Key Companies
Highest Development Stage
  • Phase II

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, potential applicable patients, drug margins, company expenses, and pricing estimates. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate rNPV, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA)and phase transition success rate(PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.