Lefelsiran Sodium is an antisense rnai oligonucleotide commercialized by Novo Nordisk, with a leading Phase I program in Alcohol Dependence. According to Globaldata, it is involved in 2 clinical trials, which were completed. GlobalData uses proprietary data and analytics to provide a complete picture of Lefelsiran Sodium’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
The revenue for Lefelsiran Sodium is expected to reach an annual total of $20 mn by 2037 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Lefelsiran Sodium Overview
Lefelsiran sodium (NN-6020) is under development for the treatment of alcohol use disorder. The drug candidates is a siRNA. The drug candidate is developed based on GalXC RNAi technology platform. It acts by targeting ALDH2. It is administered subcutaneously as a solution.
Novo Nordisk Overview
Novo Nordisk, a subsidiary of Novo Holdings AS, is a healthcare company with focus on discovering, developing, and manufacturing biological medicines. It focuses on advancing drugs for the treatment of diabetes and other serious and chronic conditions including haemophilia, human growth hormone (HGH) disorders, rare blood and rare endocrine diseases and obesity. The company’s portfolio includes pre-filled delivery systems for insulin; glucagon hypokit; cartridge; needles; vials; insulin; estradiol for hormone replacement; recombinant drugs for haemophilia; glucagon; and oral antidiabetic agents. The company markets its products through subsidiaries in North America, Europe, Asia, Latin America, Africa, the Middle East and Australia. Novo Nordisk is headquartered in Bagsvaerd, Denmark.
The company reported revenues of (Danish Krone) DKK232,261 million for the fiscal year ended December 2023 (FY2023), an increase of 31.3% over FY2022. In FY2023, the company’s operating margin was 44.2%, compared to an operating margin of 42.3% in FY2022. In FY2023, the company recorded a net margin of 36%, compared to a net margin of 31.4% in FY2022.
The company reported revenues of DKK68,060 million for the second quarter ended June 2024, an increase of 4.1% over the previous quarter.
For a complete picture of Lefelsiran Sodium’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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