Lemzoparlimab is under clinical development by AbbVie and currently in Phase I for B-Cell Non-Hodgkin Lymphoma. According to GlobalData, Phase I drugs for B-Cell Non-Hodgkin Lymphoma have a 78% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how Lemzoparlimab’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Lemzoparlimab overview

TJC-4 (lemzoparlimab) is under development for the treatment of acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), diffuse large B-cell lymphoma or indolent B-cell lymphoma, relapsed or refractory acute myeloid leukemia, myelodysplastic syndrome, primary mediastinal b-cell lymphoma, non-small-cell lung carcinoma (NSCLC), epithelial ovarian cancer, fallopian tube and primary peritoneal cancer and for relapsed and refractory and newly diagnosed multiple myeloma, solid tumor. The drug candidate is developed based on hybridoma and phage display technologies. It acts by targeting CD47. It is administered through intravenous route. It was also under development for the treatment of non-Hodgkin's lymphoma, urothelial (bladder) cancer.

It was also under development for the treatment of melanoma, gastric cancer, head and neck squamous cell carcinoma.

AbbVie overview

AbbVie is a specialty biopharmaceutical company, which discovers, develops, manufactures, and commercializes drugs for the treatment of chronic and complex diseases. Its drugs are indicated for the treatment of metabolic diseases, rheumatological diseases, neurological disorders, viral diseases, skin diseases, complications associated with cystic fibrosis, pain related to endometriosis, diseases of the gastrointestinal tract, various types of cancer, and other serious health conditions. AbbVie is also advancing its pipeline programs for the treatment of cystic fibrosis, women’s health, various cancers, neurological disorders and other autoimmune diseases. The company markets its products directly to wholesalers, distributors, health care facilities, government agencies, specialty pharmacies and independent retailers through its own distribution centers and public warehouses worldwide. AbbVie is headquartered in North Chicago, Illinois, the US.

For a complete picture of Lemzoparlimab’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.