Les Laboratoires Servier has patented a recombinant microorganism capable of producing diosmin and hesperidin. The microorganism contains specific nucleic acid sequences for enzymatic reactions leading to the production of these compounds. GlobalData’s report on Les Laboratoires Servier gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Les Laboratoires Servier, Cancer treatment biomarkers was a key innovation area identified from patents. Les Laboratoires Servier's grant share as of May 2024 was 55%. Grant share is based on the ratio of number of grants to total number of patents.
Production of diosmin and hesperidin by modified microorganism
A recently granted patent (Publication Number: US11987829B2) discloses a recombinant microorganism designed to produce specific enzymes involved in the biosynthesis of flavonoids. The microorganism contains heterologous nucleic acid sequences for flavanone 7-O-beta-D-glucosyltransferase, 6"-O-rhamnosyltransferase, and UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase, enabling the addition of glucose and rhamnose to hesperetin and diosmetin. Additionally, the microorganism includes sequences for tyrosine ammonia lyase, 4-coumarin-CoA ligase, naringenin-chalcone synthase, chalcone isomerase, flavonoid 3'-monooxygenase, O-methyltransferase, phenylalanine ammonia lyase, cinnamate 4-hydroxylase, flavone synthase, cytochrome P450 reductase, and S-adenosylmethionine synthetase, enhancing the production of various flavonoids.
Furthermore, the patent specifies that the microorganism can be a yeast or a bacterium, providing flexibility in the choice of host organism for the biosynthesis of flavonoids. The inclusion of specific enzyme sequences with at least 60% sequence identity ensures the efficient production of flavonoids with desired modifications. This innovation in genetic engineering of microorganisms opens up possibilities for the sustainable and cost-effective production of flavonoids with potential applications in pharmaceuticals, nutraceuticals, and other industries requiring these valuable compounds.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
