Ligufalimab is under clinical development by Akeso and currently in Phase II for Metastatic Colorectal Cancer. According to GlobalData, Phase II drugs for Metastatic Colorectal Cancer have a 34% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Ligufalimab’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Ligufalimab overview

Ligufalimab is under development for the treatment of acute myeloid leukemia, myelodysplastic syndrome (MDS), relapsed or refractory advanced or metastatic solid tumors and non-Hodgkin lymphoma (NHL), head and neck cancer and gastrointestinal tumor, epithelial ovarian cancer, transitional cell cancer (urothelial cell cancer), metastatic hormone refractory (castration resistant, androgen-independent) prostate cancer, head and neck cancer squamous cell carcinoma, primary peritoneal cancer, fallopian tube cancer, hepatocellular carcinoma, cervical cancer, metastatic biliary tract cancer, intrahepatic or extrahepatic cholangiocarcinoma, gallbladder cancer, pancreatic ducts adenocarcinoma, gastric cancer, adenocarcinoma of the gastroesophageal junction, esophageal squamous cell carcinoma, urothelial carcinoma, colorectal adenocarcinoma, non-small cell lung cancer, metastatic colorectal cancer, small cell lung cancer, sarcoma, triple-negative breast cancer and oral cavity cancer, oropharyngeal cancer, hypopharyngeal cancer, laryngeal cancer and recurrent or metastatic head And neck cancer squamous cell carcinoma. The drug candidate is a monoclonal antibody acts by targeting leukocyte surface antigen CD47. It is administered through intravenous drip route.

Akeso overview

Akeso is a clinical-stage biopharmaceutical company that focus on in-house discovery and development of mono and bi-specific antibody drugs. The company’s product pipeline includes Ak101 and Ak111 targeting plaque psoriasis; Ak102 for treatment of hypercholesterolemia; Ak104 against cancer; Ak105 for treating anlotinib; and Ak112 against solid tumors. It also provides kangfang integrated development platform (ACE Platform) which covers all drug R & D, including target verification, antibody discovery and also development functions. The company works in partnership with MERCK & CO Inc, Dawnrays Pharmaceutical Holdings Ltd, Sino Biopharmaceutical Ltd and China Biopharma. Akeso is headquartered in Zhongshan, Guangdong, China

For a complete picture of Ligufalimab’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.