Hemophagocytic Lymphohistiocytosis is an indication for drug development with over 10 pipeline drugs currently active. According to GlobalData, preregistered drugs for Hemophagocytic Lymphohistiocytosis have a 100% likelihood of approval (LoA) indication benchmark. GlobalData’s report assesses how phase transition success rate (PTSR) and likelihood of approval (LoA) scores for pipeline drugs in Hemophagocytic Lymphohistiocytosis compared to historical benchmarks. Buy the report here.

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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Hemophagocytic Lymphohistiocytosis overview

Hemophagocytic lymphohistiocytosis (HLH), also known as hemophagocytic or haemophagocytic syndrome is an uncommon hematologic disorder and is a life-threatening disease of severe hyperinflammation caused by uncontrolled proliferation of benign lymphocytes and macrophages that secrete high amounts of inflammatory cytokines. It is seen more often in children than in adults. HLH results from immune over-activation owing to some combination of inappropriate immunologic (CD8+ and macrophage) feedback mechanisms and chronic inflammation.

For a complete picture of PTSR and LoA scores for drugs in Hemophagocytic Lymphohistiocytosis, buy the report here.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. 

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.