Lirafugratinib hydrochloride is under clinical development by Relay Therapeutics and currently in Phase II for Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer (HER2- Breast Cancer). According to GlobalData, Phase II drugs for Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer (HER2- Breast Cancer) have a 49% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Lirafugratinib hydrochloride’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Lirafugratinib hydrochloride overview

RLY-4008 is under development for the treatment of metastatic solid tumors like intrahepatic cholangiocarcinoma biliary tract cancer and FGFR2-altered HR+/HER2- breast cancer. It is administered by oral route. The drug candidate acts by targeting fibroblast growth factor receptor 2 (FGFR2). It is being developed based on Dynamo platform.

It was under development for the treatment of gastric cancer, endometrial cancer.

Relay Therapeutics overview

Relay Therapeutics ) is a clinical-stage precision medicines company that develops oncology and generic drugs. The company’s pipeline products include RLY-4008, RLY-2608, GDC-1971, RLY-5836 and GDC-1971 for the treatment of a variety of cancers. Its RLY-4008 is an oral small molecule inhibitor of fibroblast growth factor receptor 2 (FGFR2), for patients with advanced or metastatic FGFR2-altered solid tumors. The company utilizes the Dynamo platform, which integrates an array of leading-edge computational and experimental approaches designed for drug-protein targets. Relay Therapeutics is headquartered in Cambridge, Massachusetts, the US.

For a complete picture of Lirafugratinib hydrochloride’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 18 March 2024

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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.