LM-302 is under clinical development by Turning Point Therapeutics and currently in Phase II for Bile Duct Cancer (Cholangiocarcinoma). According to GlobalData, Phase II drugs for Bile Duct Cancer (Cholangiocarcinoma) have a 33% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how LM-302’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

LM-302 overview

LM-302 is under development for the treatment of CLDN18.2-positive advanced solid tumors including gastric cancer, gastroesophageal (GE) junction carcinomas, adenocarcinoma of the gastroesophageal junction, esophageal cancer, colorectal cancer, ovarian cancer, pancreatic cancer and bile duct cancer (cholangiocarcinoma). It is administered through intravenous drip route as infusion and acts by targeting claudin 18.2 (CLDN18.2).

Turning Point Therapeutics overview

Turning Point Therapeutics (TP therapeutics) is a biopharmaceutical company. It designs and develops clinical stage small molecule, targeted oncology therapies to address key limitations of existing lung cancer therapies. Its pipeline products include Repotrectinib, macrocyclic tyrosine kinase inhibitor, TPX-0022, multi-targeted kinase inhibitor, TPX-0046, a multi-targeted orally bioavailable TKI, TPX – 013 and ALK inhibitor. TP therapeutics also provides clinical trial activities such as TRIDENT-1 and compassionate use programs. The company’s macrocyclic platform addresses the issues of emerging treatment resistance and toxicities that limit duration of treatment. It operates in the US and Switzerland. TP Therapeutics is headquartered in San Diego, California, the US.

For a complete picture of LM-302’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.