LN-145 is a cell therapy commercialized by Iovance Biotherapeutics, with a leading Phase II program in Cervical Cancer. According to Globaldata, it is involved in 9 clinical trials, of which 2 were completed, and 7 are ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of LN-145’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
The revenue for LN-145 is expected to reach an annual total of $246 mn by 2037 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Lifileucel (LN-145) is under development for the treatment of metastatic melanoma, metastatic triple negative breast cancer, soft tissue sarcoma, osteosarcoma, bone sarcoma, chondrosarcoma, giant cell tumor of bone, anaplastic thyroid cancer, ovarian cancer, cervical cancer, head and neck squamous cell carcinoma and advanced or metastatic non-small cell lung cancer (NSCLC). The therapeutic candidate is administered as intravenous route. It constitutes of tumor infiltrating lymphocytes (TILs) isolated from the patient’s tumor further expanded and then infused back to the patient enabling patient robust immune response.
It was under development for the treatment of metastatic transitional cell cancer of the urothelium including renal pelvis cancer, ureters cancer, urinary bladder cancer and urethra cancer and refractory HPV-associated cancer.
Iovance Biotherapeutics Overview
Iovance Biotherapeutics (Iovance) is a biotechnology company that focuses on the development and commercialization of novel immunotherapy products for treating various cancers. It develops products based on its tumor-infiltrating lymphocyte (TIL) technology. The company’s lead product candidates include lifileucel is an autologous, ready-to-infuse cell therapy indicated for the treatment of melanoma and metastatic cervical cancer; and LN-145 for the treatment of head and neck cancer. The company also focuses on investigating TIL therapy for treatment of a range of cancer. The company operates a research facility in Tampa, Florida. Iovance is headquartered in San Carlos, California, the US.
The operating loss of the company was US$342.7 million in FY2021, compared to an operating loss of US$261.9 million in FY2020. The net loss of the company was US$342.3 million in FY2021, compared to a net loss of US$259.6 million in FY2020.
For a complete picture of LN-145’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.