Loncastuximab tesirine is under clinical development by ADC Therapeutics and currently in Phase II for Mantle Cell Lymphoma. According to GlobalData, Phase II drugs for Mantle Cell Lymphoma have a 31% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Loncastuximab tesirine’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
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Loncastuximab tesirine overview
Loncastuximab Tesirine (Zynlonta) is a CD19-directed antibody and alkylating agent conjugate, consisting of a humanized IgG1 kappa monoclonal antibody conjugated to SG3199, a pyrrolobenzodiazepine (PBD) dimer cytotoxic alkylating agent .It is formulated as lyophilized powder for solution for intravenous route of administration. Zynlonta is indicated for the treatment of adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy, including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, DLBCL arising from low-grade lymphoma, high-grade B-cell lymphoma, and B-cell non-Hodgkin Lymphoma.
See Also:
loncastuximab tesirine (ADCT-402) is under development for the treatment of B-cell non-hodgkin lymphoma including Burkitt lymphoma, chronic lymphocytic leukemia (CLL), marginal zone B-cell lymphoma, extranodal marginal zone b-cell lymphoma, splenic marginal zone b-cell lymphoma, Waldenstrom macroglobulinemia (lymphoplasmacytic lymphoma), relapsed and refractory diffuse large B-cell lymphoma, follicular lymphoma and mantle cell lymphoma. The therapeutic candidate is administered intravenously. The drug candidate is an antibody drug conjugate consists of a monoclonal antibody combined to pyrrolobenzodiazepines (PBD) based warheads. The drug candidate targets CD19. The warheads are developed using pyrrolobenzodiazepines (PBDs) technology. It was under development for primary mediastinal large B-cell lymphoma, relapsed or refractory B-cell acute lymphocytic leukemia.
ADC Therapeutics overview
ADC Therapeutics is a biotechnology company that develops antibody-drug conjugates (ADCs) to treat hematologic malignancies and solid tumors. It offers Zynlonta, a CD-19-directed antibody for treatment of e B-cell lymphoma in adult patients. The company is provides Loncastuximab Tesirine (Lonca)and Camidanlumab Tesirine (Cami). ADC Therapeutics develops ADCT-602 drug for B-cell acute lymphoblastic leukemia, ADCT-601 targeting AXL in solid tumors, ADCT-901 against ovarian, triple-negative breast cancer and advanced solid tumors and ADCT-701 drug targeting DLK-1 in neuroblastoma, hepatocellular carcinoma, small cell lung cancer and myeloid leukemia. The company has operations in London, the UK and New Providence, and San Mateo, the US. ADC Therapeutics is headquartered in Lausanne, Switzerland.
For a complete picture of Loncastuximab tesirine’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
