Lonza Group has been granted a patent for multiparticulate compositions that include over 60% active agents and specific gelling agents, prepared using an aqueous-based spray and congeal process. The compositions also contain inorganic salts and water-soluble polymers, enhancing their formulation. GlobalData’s report on Lonza Group gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Lonza Group, Nanoemulsion cosmetics was a key innovation area identified from patents. Lonza Group's grant share as of June 2024 was 59%. Grant share is based on the ratio of number of grants to total number of patents.
Multiparticulate compositions with active and gelling agents
The granted patent US12036322B2 describes a multiparticulate composition characterized by a plurality of gelled particles. These particles contain over 60 weight percent (wt %) of an active agent, along with a gelling agent (1 wt % to 6 wt %) that can include substances such as gellan gum, carrageenan, agar, pectin, gelatin, or combinations thereof. Additionally, the composition incorporates 0.05 wt % to 1 wt % of an inorganic salt, which may be an alkali metal or alkaline earth metal salt, and 4 wt % to 34 wt % of a water-soluble polymer. The patent outlines specific mass ratios for the components, including the gelling agent to inorganic salt and the water-soluble polymer to both the gelling agent and inorganic salt, ensuring a precise formulation for effective performance.
The patent also details a method for producing this multiparticulate composition, which involves preparing an aqueous suspension that exceeds the solubility limit of the active agent. This suspension is then atomized into droplets at a temperature above the gelation point, followed by cooling to allow the gelling agent to form gelled particles. The process can include various techniques, such as using a rotary atomizer for droplet formation and convective cooling. The resulting gelled particles can be further processed into dosage forms like capsules, tablets, or powder mixes, and may also include additional features such as colorants or outer coatings. This innovative composition and method aim to enhance the delivery and efficacy of active agents in pharmaceutical applications.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
