LP-284 is under clinical development by Lantern Pharma and currently in Phase I for Diffuse Large B-Cell Lymphoma. According to GlobalData, Phase I drugs for Diffuse Large B-Cell Lymphoma have a 74% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how LP-284’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

LP-284 overview

LP-284 is under development for the treatment of solid tumours, relapsed or refractory non-Hodgkin’s lymphoma (NHL), including DLBCL, mantle cell lymphoma (MCL) and double hit lymphoma (DHL) and other high-grade B-cell lymphomas (HGBL), pediatric cancer like Ewing Sarcoma, malignant rhabdomyosarcoma, alveolar rhabdomyosarcoma and hematological cancers including multiple myeloma and leukemia. The drug candidate is a synthetic illudin S derivative belonging to acylfulvene (AF) class. It acts as DNA damaging agent. The drug is being developed based on AI and machine learning (ML) platform, RADR. It is administered through intravenous route.

Lantern Pharma overview

Lantern Pharma is a clinical-stage biopharmaceutical company. It develops precision cancer drugs using machine learning techniques, genomic data and precision oncology trials. The company’s pipeline products include LP-100 and LP-184 are non-hormone, non-chemotherapy, DNA Damage Repair (DDR) inhibitors showing multiple cytotoxic effects on tumor cell biology including DNA adduct formation, RNA polymerase stalling and redox protein modification in prostate, ovarian, renal, lung and brain cancers and LP-300 is a first-in-class combination agent indicated for non-small cell lung cancer (NCSLC). Lantern Pharma utilizes Response Algorithm for Drug Positioning & Rescue (RADR) which is an integrated data analytics and machine learning-based platform for patient genetic profiling for robust drug response prediction. The company partners with hospitals, diagnostics, non-profit organizations and universities to accelerate the development of small molecule-based therapies in oncology. Lantern Pharma is headquartered in Dallas, Texas, the US.

For a complete picture of LP-284’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 22 April 2024

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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.