Mavacamten is a Small Molecule owned by Bristol-Myers Squibb, and is involved in 22 clinical trials, of which 14 were completed, 6 are ongoing, and 2 are planned.

Mavacamten acts by inhibiting smooth muscle myosin. The muscle contractility is driven by smooth muscle myosin. The drug candidate blocks the function of the myosin motor protein central to smooth muscle contraction and leads to the relaxation of the muscle.

The revenue for Mavacamten is expected to reach a total of $24.6bn through 2038. This change impacts the valuation of this asset and is an important factor to understand the current value of the drug in a clinical process. View the complete picture with the Mavacamten NPV Report.

Mavacamten was originated by MyoKardia and is currently owned by Bristol-Myers Squibb.

Mavacamten Overview

Mavacamten (Camzyos) is an allosteri a modulator of β-cardiac myosin It is formulated as capsules for oral route od administration, Camzyos is indicated for the treatment of adults with symptomatic New York Heart Association (NYHA) class II-III obstructive hypertrophic cardiomyopathy (HCM) to improve functional capacity and symptoms. Mavacamten (formerly MYK-461) is under development for the treatment of symptomatic obstructive hypertrophic cardiomyopathy, non-obstructive hypertrophic cardiomyopathy (HCM) as well as diastolic heart failure. The drug candidate is administered orally as capsules. It is a first in class allosteric modulator. It acts by targeting myosin. It is developed based on MyoKardia's drug discovery platform.

Bristol-Myers Squibb Overview

Bristol-Myers Squibb (BMS) is a specialty biopharmaceutical company that is engaged in discovery, development, licensing and manufacturing, marketing, distribution and sale of medicines and related medical products to patients with serious diseases. Its primary focus is on cancer, cardiovascular, immunology and fibrotic therapeutic projects. The company offers its products across the world to wholesalers, retail pharmacies, hospitals, medical professionals and government entities. BMS provides its products in the US, Europe, and Japan. The company conducts research to focus on the discovery and development of novel medicines that address serious diseases in areas of significant unmet medical need. BMS is headquartered in New York City, New York, the US.

The company reported revenues of (US Dollars) US$46,385 million for the fiscal year ended December 2021 (FY2021), an increase of 9.1% over FY2020. The operating profit of the company was US$8,615 million in FY2021, compared to an operating loss of US$6,847 million in FY2020. The net profit of the company was US$6,994 million in FY2021, compared to a net loss of US$9,015 million in FY2020. The company reported revenues of US$11,218 million for the third quarter ended September 2022, a decrease of 5.6% over the previous quarter.

Quick View – Mavacamten

Report Segments
  • Innovator (NME)
Drug Name
  • Mavacamten
Administration Pathway
  • Oral
Therapeutic Areas
  • Cardiovascular
Key Companies
Highest Development Stage
  • Marketed

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, potential applicable patients, drug margins, company expenses, and pricing estimates. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate rNPV, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA)and phase transition success rate(PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.