MEDI-0457 is under clinical development by AstraZeneca and currently in the Phase II in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.
According to GlobalData, the latest event to affect MEDI-0457’s likelihood of approval (LoA) and phase transition for Head And Neck Cancer Squamous Cell Carcinoma took place on 08 Dec 2022, which decreased the likelihood that the drug progresses to the next phase in its clinical pathway and decreased the likelihood of final approval for this indication.
GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their MEDI-0457 Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.
MEDI-0457 (VGX-3100 plus DNA-based IL-12 cytokine) is under development for the treatment of HPV-caused head and neck squamous cell carcinoma (HNSCC), HPV positive oropharyngeal squamous cell carcinoma, cervical cancer, vulvar cancer, anal, penile cancer and vaginal cancer, newly diagnosed glioblastoma. It is administered intramuscularly by electroporation. INO-3112 is DNA-based combination immunotherapeutic composed of VGX-3100 DNA plasmids encoding the E6 and E7 genes of human papilloma virus (HPV) subtypes 16 and 18 combined with INO-9012, a DNA plasmid encoding interleukin-12 (IL-12). The vaccine is developed based on SynCon DNA vaccine technology, ASPIRE technology and CELLECTRA electroporation-based delivery technology. It was also under development for advanced unresectable or metastatic urothelial carcinoma.
AstraZeneca is a biopharmaceutical company, which is focused on discovery, production and commercialization of a range of prescription drugs. It develops products related to therapy areas such as respiratory, cardiovascular, renal and metabolic diseases, cancer, autoimmune, infection and neurological diseases. The company’s product portfolio includes biologics, prescription pharmaceuticals and vaccines. AstraZeneca sells its products through wholly-owned local marketing companies, distributors and local representative offices. The company markets its products to primary care and specialty care physicians. The COVID-19 Vaccine AstraZeneca has been approved for conditional marketing or emergency use. The company operates in Europe, the Americas, Asia, Africa and Australasia. AstraZeneca is headquartered in Cambridge, Cambridgeshire, the UK.
Quick View MEDI-0457 LOA Data
|Highest Development Stage|