The Melanoma Associated Antigen 3 pipeline drugs market research report outlays comprehensive information on the Melanoma Associated Antigen 3 targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA), and molecule type. GlobalData’s report assesses the drugs in the Melanoma Associated Antigen 3 pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline. Buy the report here.
The report also covers products from therapy areas such as Oncology which include the indications Non-Small Cell Lung Cancer, and Melanoma. It also reviews key players involved in Melanoma Associated Antigen 3 targeted therapeutics development with respective active and dormant or discontinued products.
The Melanoma Associated Antigen 3 pipeline targets constitutes close to 18 molecules. Out of which, approximately 12 molecules are developed by companies and the remaining by the universities/institutes. The molecules developed by companies in Phase III, Phase II, Phase I, Preclinical, and Discovery stages are 1, 5, 1, 2, and 3 respectively. Similarly, the universities portfolio in Phase III, Phase I, Phase 0, and Preclinical comprises 1, 3, 1, and 1 molecule.
Melanoma Associated Antigen 3 overview
Melanoma-Associated Antigen 3, commonly known as MAGE-A3, serves as an activator of the ubiquitin ligase function of RING-type zinc finger-containing E3 ubiquitin-protein ligases. It also functions as a repressor of autophagy. This protein enhances the ubiquitin ligase activity of TRIM28 and stimulates the ubiquitination of p53/TP53 by TRIM28. Its proposed mechanism of action involves the recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. MAGE-A3 plays a role in embryonal development and may be associated with tumor transformation or certain aspects of tumor progression. In vitro studies have shown that it promotes cell viability in melanoma cell lines. Additionally, it is recognized as an antigen on melanoma cells by autologous cytolytic T-lymphocytes.
For a complete picture of Melanoma Associated Antigen 3’s drug pipeline, buy the report here.
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