Merestinib is under clinical development by Eli Lilly and Co and currently in Phase II for Metastatic Biliary Tract Cancer. According to GlobalData, Phase II drugs for Metastatic Biliary Tract Cancer have a 37% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Merestinib’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Merestinib (LY-2801653) is under development for the treatment of solid tumors including metastatic biliary tract adenocarcinoma, gallbladder cancer, non-small cell lung cancer. It is administered orally. The drug candidate is a new chemical entity (NCE). It acts by targeting c-Met, other receptor tyrosine oncokinases including MST1R, FLT3, AXL, MERTK, TEK, ROS1, and DDR1/2 and the serine/threonine kinases MKNK1/2. It was also under development for uveal melanoma with liver with metastasis, bone metastasis associated with breast cancer, gastric cancer, adenocarcinoma of gastroesophageal junction, metastatic colorectal cancer, adenocarcinoma of the colon or rectum, cholangiocarcinoma, non-small cell lung cancer, heamatological cancers including non-Hodgkin lymphoma, mantle cell lymphoma, relapsed and refractory acute myeloid leukemia and head and neck squamous cell carcinoma.
Eli Lilly and Co overview
Eli Lilly and Co (Lilly) is a healthcare company that is engaged in the discovery, development, and marketing of human healthcare products. The company offers medicines for cardiovascular conditions, diabetes, endocrinology, cancer, neurological problems, immune disorders, men’s health and musculoskeletal problems. The company distributes its pharmaceutical health products through independent wholesale distributors. Lilly conducts research and development activities to discover and deliver innovative medicines. It also promotes products through sales representatives and marketing agreements with other pharmaceutical companies. The company also offers its products in North America, South America, Europe, South Asia, the Middle East, Africa and North Asia-Pacific. Lilly is headquartered in Indianapolis, Indiana, the US.
For a complete picture of Merestinib’s drug-specific PTSR and LoA scores, buy the report here.