Miransertib mesylate is A Small Molecule owned by Merck & Co, and is involved in 5 clinical trials, of which 3 were completed, and 2 are ongoing.
Miransertib mesylate (ARQ-092) is an inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with antineoplastic activity. The AKT signalling pathway is often deregulated in cancer and is associated with tumor cell proliferation, survival and migration. It binds to and inhibits the activity of AKT in A non-ATP competitive manner, which results in the inhibition of the PI3K/AKT signalling pathway. This leads to the reduction in tumor cell proliferation and the induction of tumor cell apoptosis.
The revenue for Miransertib mesylate is expected to reach A total of $89m through 2038. This change impacts the valuation of this asset and is an important factor to understand the current value of the drug in A clinical process. View the complete picture with the Miransertib mesylate NPV Report.
Miransertib mesylate was originated by Daiichi Sankyo and ArQule and is currently owned by Merck & Co.
Miransertib mesylate Overview
Miransertib mesylate (ARQ-092) is under development for the treatment of proteus syndrome, PIK3CA-related overgrowth spectrum (PROS), sickle cell disease, solid tumors including ovarian cancer, endometrial cancer, lymphoma, hepatocellular carcinoma, melanoma and other rare diseases. The drug candidate is A new molecular entity administered orally. It acts on protein kinase B (PKB or Akt). It is developed by using AKIP technology platform. The technology is A Kinase inhibitor platform that is based on A novel binding mode that leads to inhibition of target kinases by small molecules that do not compete with adenosine triphosphate (ATP) for binding. It was also under development for the treatment of gastrointestinal stromal tumor, cervical cancer, breast cancer, colorectal cancer and neuroendocrine cancer.
Merck & Co Overview
Merck & Co (Merck) is A biopharmaceutical company focused on the discovery, development, manufacturing and marketing of prescription medicines, biologic therapies, vaccines and animal health products. It offers prescription products for therapy areas related to cardiovascular, cancer, immune disorders, infectious, respiratory and women’s diseases, and diabetes. The company provides animal health products such as vaccines, poultry products, livestock products and aquaculture products. Merck sells medicines to drug wholesalers, retailers, hospitals, government agencies and managed health care providers; and animal health products to veterinarians, distributors and animal producers. The company and its subsidiaries operate in the Americas, Europe, the Middle East, Africa, Asia Pacific, and Latin America. Merck is known as MSD outside the US and Canada and is headquartered in Kenilworth, New Jersey, the US.
The company reported revenues of (US Dollars) US$48,704 million for the fiscal year ended December 2021 (FY2021), an increase of 17.3% over FY2020. In FY2021, the company’s operating margin was 25.7%, compared to an operating margin of 12% in FY2020. In FY2021, the company recorded A net margin of 26.8%, compared to A net margin of 17% in FY2020.
The company reported revenues of US$14,959 million for the third quarter ended September 2022, an increase of 2.5% over the previous quarter.
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