Mirvetuximab soravtansine is under clinical development by ImmunoGen and currently in Phase II for Triple-Negative Breast Cancer (TNBC). According to GlobalData, Phase II drugs for Triple-Negative Breast Cancer (TNBC) have a 25% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Mirvetuximab soravtansine’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Mirvetuximab soravtansine overview
Mirvetuximab Soravtansine (Elahere, Mirvetuximab Soravtansine-GYNX) is an immunoconjugate consisting of the humanized monoclonal antibody. It is formulated as a solution for the intravenous route of administration, Elahere is indicated for the treatment of adult patients with FRα positive, platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer, who have received one to three prior systemic treatment regimens.
Mirvetuximab soravtansine (IMGN-853) is under development for the treatment of FR alpha positive solid tumors such as metastatic triple negative breast cancer, platinum-resistant, advanced high-grade epithelial ovarian cancer, advanced-stage ovarian cancer (first line), primary peritoneal cancer and fallopian tube cancer. The drug candidate is administered through intravenous route. It is an antibody-drug conjugate consisting of cytotoxic maytansinoid, DM4, covalently linked to the humanized monoclonal antibody M9346A, which selectively binds to folate receptor 1 (FOLR1). The drug candidate is based on targeted antibody payload (TAP) technology. It was also under development for the treatment of renal cell adenocarcinoma, endometrial cancer and non-small cell lung adenocarcinoma,
ImmunoGen is a clinical-stage biotechnology company that focuses on the development of novel antibody-drug conjugates (ADCs) that facilitate targeted therapies for the treatment of cancer. Its pipeline product candidates include mirvetuximab soravtansine for the treatment of platinum-resistant ovarian cancer; IMGN632 for AML, and blastic plasmacytoid dendritic cell neoplasm (BPDCN); IMGC936, the company’s product candidate for a range of solid tumors; and IMGN151, its next-generation anti-FRa candidate in the preclinical development stage. ImmunoGenorporates its proprietary product development ADC technology to enhance the anticancer activity of monoclonal antibodies. The company has direct operations in the US, Ireland, and the UK. ImmunoGen is headquartered in Waltham, Massachusetts, the US.
For a complete picture of Mirvetuximab soravtansine’s drug-specific PTSR and LoA scores, buy the report here.