MK-5475 is a small molecule commercialized by Merck, with a leading Phase III program in Pulmonary Arterial Hypertension. According to Globaldata, it is involved in 7 clinical trials, of which 5 were completed, and 2 are ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of MK-5475’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
The revenue for MK-5475 is expected to reach an annual total of $63 mn by 2034 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
MK-5475 Overview
MK-5475 is under development for the treatment of pulmonary hypertension, pulmonary vascular resistance in patients with pulmonary arterial hypertension including idiopathic, heritable, drug- or toxin-induced pulmonary hypertension and pulmonary hypertension associated with connective tissue disease or congenital heart disease and pulmonary hypertension associated with chronic obstructive pulmonary disease. The drug candidate is administered through inhalation route. It was also under development for hypoxemia due to Coronavirus disease 2019 (COVID-19) pneumonia. The drug candidate acts by targeting soluble guanylate cyclase (SGC).
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Merck Overview
Merck is a biopharmaceutical company focused on the discovery, development, manufacturing and marketing of prescription medicines, biologic therapies, vaccines, and animal health products. It offers prescription products for therapy areas related to cardiovascular, cancer, immune disorders, infectious, respiratory, and diabetes. The company provides animal health products such as vaccines, poultry products, livestock products and aquaculture products. Merck sells medicines to drug wholesalers, retailers, hospitals, government agencies and managed health care providers; and animal health products to veterinarians, distributors and animal producers. The company and its subsidiaries operate in the Americas, Europe, the Middle East, Africa, Asia Pacific, and Latin America. Merck is known as MSD outside the US and Canada and is headquartered in Kenilworth, New Jersey, the US.
For a complete picture of MK-5475’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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