Mogamulizumab is under clinical development by Kyowa Kirin and currently in Phase I for Oral Cancer. According to GlobalData, Phase I drugs for Oral Cancer does not have sufficient historical data to build an indication benchmark PTSR for Phase I. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the Mogamulizumab LoA Report. Buy the report here.

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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Mogamulizumab overview

Mogamulizumab (Poteligeo) is a glyco-engineered humanized monoclonal antibody targeting C-C chemokine receptor 4 (CCR4). It is designed by utilizing the company's Potelligent technology platform. It is formulated as solution and concentrate solution for intravenous route of administration. Poteligeo is indicated for the treatment of CCR4 positive adult T cell leukemia, lymphoma. It is also indicated for recurrent or refractory CCR4 positive peripheral T cell lymphoma and skin T-cell lymphoma. It is also indicated for the treatment of adult patients with relapsed or refractory mycosis fungoides (MF) or Sezary syndrome (SS) after at least one prior systemic therapy.

Poteligeo is under development for treatment of oral squamous cell carcinoma, including mycosis fungoides and sezary syndrome, angioimmunoblastic T-cell lymphoma, anaplastic large-cell lymphoma and peripheral T/NK-cell lymphoma. It was also under development for asthma, HTLV-1 associated myelopathy (HAM) (Spinal cord disorder), peripheral T-cell lymphoma, allergic rhinitis, non-small cell lung cancer, relapsed/ refractory adult T-cell leukemia, and cutaneous T-cell lymphoma, metastatic triple negative breast cancer, metastatic hepatocellular carcinoma, gastric cancer, gastric adenocarcinoma, esophageal squamous cell carcinoma, non-small-cell lung carcinoma and solid tumor. It was also under development for renal cell carcinoma.

Kyowa Kirin overview

Kyowa Kirin, a subsidiary of Kirin Holdings Co Ltd, is a biotechnology company focused on research and development. It is involved in the discovery, development, production and commercialization of pharmaceuticals and biotechnology products. The company offers drugs in the areas of nephrology, oncology, immunology and allergy, central nervous system among others. Its development pipeline consists of various protein, antibody and small molecule formulations for the treatment of neutropenia, anemia, chronic idiopathic thrombocytopenic purpura, angina pectoris, hypertension, allergic rhinitis, epilepsy, behavioral or personality disorders and others. The company operates through a network of subsidiaries in the US, Europe and Asia. Kyowa Kirin is headquartered in Tokyo, Japan.

For a complete picture of Mogamulizumab’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 22 January 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.