Momelotinib dihydrochloride is under clinical development by GSK and currently in Phase II for Refractory Acute Myeloid Leukemia. According to GlobalData, Phase II drugs for Refractory Acute Myeloid Leukemia have a 21% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Momelotinib dihydrochloride’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Momelotinib dihydrochloride overview

Momelotinib dihydrochloride (Ojjaara) acts as anti-cancer drug. It is formulated as film coated tablets for oral route of administration. Ojjaara is indicated for the treatment of intermediate or high-risk myelofibrosis (MF), including primary MF or secondary MF, (postpolycythemia vera (PV) and post-essential thrombocythemia (ET)), in adults with anemia.

Momelotinib (CYT-387) is under development for the treatment of myelofibrosis, primary myelofibrosis (PMF), secondary myelofibrosis, polycythemia vera myelofibrosis (PPV-MF), thrombocythaemia myelofibrosis and relapsed and refractory acute myeloid leukemia. It is administered orally. It is Janus Kinase (JAK) 1/2 and Activin Receptor Type 1 (ACVR1) Inhibitor. It was also under development for the treatment of metastatic pancreatic ductal adenocarcinoma, metastatic non-small cell lung cancer, post-polycythemia vera (PV) and essential thrombocythemia.

GSK overview

GSK is a healthcare company that focuses on developing, manufacturing and commercializing general medicines, specialty medicines and vaccines. It offers drugs for the treatment of diseases such as HIV, respiratory, cancer, immuno-inflammation, anti-viral, central nervous system (CNS), metabolic, cardiovascular, and urogenital, anti-bacterial, dermatology and rare diseases. The company also offers over-the-counter (OTC) products for pain relief, oral health, nutrition, skin health and gastrointestinal diseases. GSK’s vaccine portfolio covers various diseases including hepatitis, diphtheria, tetanus, whooping cough, rotavirus and HPV infections, measles and bacterial meningitis, among others. The company sells its products through wholesalers, pharmacies, hospitals, physicians and other groups worldwide. GSK is headquartered in Brentford, Middlesex, the UK.

For a complete picture of Momelotinib dihydrochloride’s drug-specific PTSR and LoA scores, buy the report here.

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.