MP-0310 is under clinical development by Molecular Partners and currently in Phase I for Malignant Mesothelioma. According to GlobalData, Phase I drugs for Malignant Mesothelioma have a 77% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how MP-0310’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
MP-0310 is under development for the treatment of solid tumors including colorectal cancer, ovarian cancer, endometrial cancer, gastric cancer, pancreatic cancer, anal cancer, cervical cancer, squamous cell cancer of the head and neck, mesothelioma, prostate cancer, non-small cell lung cancer, melanoma, urothelial or bladder cancer, microsatellite tumors and cutaneous squamous cell carcinoma. The drug candidate is administered through intravenous route. It is a multi-DARPin and a tumor-restricted T-cell co-stimulator. It targets 4-1BB (CD137) protein mainly expressed on activated CD4+ and CD8+ T cells, activated B cells, and natural killer (NK) cells and fibroblast activating protein (FAP) which is expressed in stroma of many tumor cells. It is developed based on DARPin technology.
Molecular Partners overview
Molecular Partners is a clinical-stage bio-pharmaceutical company that develops biological drugs. The company offers advanced small protein therapies such as abicipar, a designed ankyrin repeat protein-based anti-angiogenic drug developed for diabetic macular edema and wet age- macular degeneration. It also develops drugs on DARPin base technology and other product candidates. Molecular Partners develops products for ophthalmic conditions, cancer, immune disorders and other indications. The company also provides clinical trial services and small protein therapies called Darpin therapeutics. It has partnership with a pharmaceutical company to strengthen drug platforms through in-house development, licensing and collaboration. Molecular Partners is headquartered in Zurich, Switzerland.
For a complete picture of MP-0310’s drug-specific PTSR and LoA scores, buy the report here.