Navenibart is a monoclonal antibody commercialized by Astria Therapeutics, with a leading Phase II program in Hereditary Angioedema (HAE) (C1 Esterase Inhibitor [C1-INH] Deficiency). According to Globaldata, it is involved in 4 clinical trials, of which 1 was completed, 2 are ongoing, and 1 is planned. GlobalData uses proprietary data and analytics to provide a complete picture of Navenibart’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

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The revenue for Navenibart is expected to reach an annual total of $518 mn by 2040 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

Navenibart Overview

Navenibart (STAR-0215) is under development for the treatment of hereditary angioedema. The drug candidate acts by targeting plasma kallikrein. It is administered through subcutaneous route.

Astria Therapeutics Overview

Astria Therapeutics (Astria), formerly Catabasis Pharmaceuticals, is a biopharmaceutical company that discovers and develops novel therapeutics for rare allergic and immunological diseases. The company’s lead product candidate is STAR-0215, a long-acting monoclonal antibody inhibitor of plasma kallikrein for the treatment of hereditary angioedema (HAE). Its STAR-0215, against hereditary angioedema (HAE), is a rare genetic disorder that causes unpredictable attacks of swelling in the face, limbs, abdomen and airway. The company operates in Massachusetts and Delaware. Astria is headquartered in Boston, Massachusetts, the US.
The operating loss of the company was US$83 million in FY2023, compared to an operating loss of US$53.5 million in FY2022. The net loss of the company was US$72.9 million in FY2023, compared to a net loss of US$51.8 million in FY2022.

For a complete picture of Navenibart’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.