Navtemadlin is under clinical development by Kartos Therapeutics and currently in Phase I for Refractory Acute Myeloid Leukemia. According to GlobalData, Phase I drugs for Refractory Acute Myeloid Leukemia have a 68% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how Navtemadlin’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Navtemadlin overview

Navtemadlin is under development for the treatment of relapsed or refractory small cell lung cancer, primary myelofibrosis, polycythemia vera, post-polycythemia vera myelofibrosis (PPV-MF), relapsed/refractory diffuse large B-cell lymphoma or relapsed/refractory chronic lymphocytic leukemia, endometrial cancer, Merkel cell carcinoma, post-essential thrombocythemia myelofibrosis (Post-ET MF) and relapsed and refractory acute myeloid leukemia, soft tissue sarcoma, liposarcoma, metastatic breast cancer and non-small cell lung cancer. The drug candidate is administered through oral route as tablet. It acts by targeting murine double minute 2 (Mdm2).

It was also under development for relapsed, refractory multiple myeloma, chronic myelocytic leukemia, metastatic cutaneous melanoma, glioblastoma multiforme (GBM) and recurrent glioblastoma multiforme (GBM).

Kartos Therapeutics overview

Kartos Therapeutics is a clinical stage biopharmaceutical company dedicated to the development of novel, targeted therapeutics. Kartos Therapeutics is headquartered in Redwood City, California, the US.

For a complete picture of Navtemadlin’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.