Northwest Biotherapeutics. has been granted a patent for a cell culture system that enhances immunotherapeutic product manufacturing. The system features interchangeable cartridges, multiple connected chambers for parallel processing, and methods for recycling cell culture medium, improving scalability, flexibility, and contamination prevention. GlobalData’s report on Northwest Biotherapeutics gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Northwest Biotherapeutics, Personalized cancer vaccines was a key innovation area identified from patents. Northwest Biotherapeutics's grant share as of July 2024 was 33%. Grant share is based on the ratio of number of grants to total number of patents.
Improved cell culture systems for scalable immunotherapeutic manufacturing
The granted patent US12071605B2 outlines a method for culturing cells that incorporates a sophisticated system designed to optimize the cell culture process. This system includes a cell culture chamber equipped with cells, multiple inlets and outlets, a perfusion fluid reservoir, a waste fluid reservoir, and at least one pump. The method involves the continuous movement of perfusion fluid, which contains a cell culture medium, through the chamber to ensure proper perfusion of the cells. Used cell culture medium is removed from the chamber, and its parameters are assessed to determine if they meet a predetermined threshold. If the parameters are satisfactory, portions of the used medium can be recycled back into the chamber, with the recycling rate influenced by factors such as gas exchange and nutrient supply requirements.
Additionally, the method allows for the combination of used cell culture medium with fresh medium before returning it to the chamber. Parameters such as glucose, lactate, and other metabolites can be measured using sensors linked to the chamber or waste reservoir. If the assessed parameters do not meet the required standards, the used medium is discarded, and fresh medium is introduced. The system is designed to facilitate essential processes like gas exchange and nutrient supply, ensuring optimal conditions for cell growth. The use of valves to control the flow of medium between the chamber and waste reservoir further enhances the efficiency of the cell culture process. Overall, this patent presents a comprehensive approach to cell culture that emphasizes recycling and real-time monitoring of culture conditions.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
