Organovo. has patented a method for fabricating three-dimensional biological tissues using bioprinting. The process involves preparing a bio-ink with living cells, extruding it onto a surface, and subjecting it to specific low-temperature conditions for optimal tissue development. GlobalData’s report on Organovo gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Organovo, 3D Bioprinting was a key innovation area identified from patents. Organovo's grant share as of June 2024 was 39%. Grant share is based on the ratio of number of grants to total number of patents.
Bioprinting three-dimensional biological tissues using low temperatures
The granted patent US12037603B2 outlines a method for fabricating three-dimensional engineered biological tissues using a bio-ink composed of living cells. The process involves several key steps: preparing the bio-ink, which can be in a viscous liquid, semi-solid, or solid form; depositing the bio-ink onto a surface through extrusion bioprinting; and subjecting the bio-ink to a hypothermic hold at temperatures between 2°C and 10°C. Following this, the bio-ink is incubated at a temperature ranging from 18°C to 37°C. Notably, the method emphasizes that the bio-ink should not be exposed to any cross-linkers during the hypothermic hold, and it can include test substances for evaluating tissue responses.
Additionally, the patent claims highlight that the method can reduce apoptosis in the bioprinted tissue compared to tissues fabricated through other methods. The bio-ink may consist of a single human cell type or a combination, such as renal fibroblasts and human umbilical vein endothelial cells (HUVECs). The process can also involve multiple bio-inks, each subjected to similar incubation conditions, and the biological tissue produced is free from pre-formed scaffolds. The hypothermic hold is limited to a maximum of 60 minutes, ensuring that the integrity of the living cells is maintained throughout the fabrication process.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
